Evidence map›Paper›PMID 37528153›Full record

ArticleScientific reports2023

Size at birth predicts later brain volumes.

Samson Nivins, Eleanor Kennedy, Christopher McKinlay, Benjamin Thompson, Jane E Harding, Children with HYpoglycemia and Their Later Development (CHYLD) Study Team

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Samson NivinsLiggins Institute, University of Auckland, Building 503, Level 2, 85 Park Road, Auckland, New Zealand.
Eleanor KennedyLiggins Institute, University of Auckland, Building 503, Level 2, 85 Park Road, Auckland, New Zealand.
Christopher McKinlayLiggins Institute, University of Auckland, Building 503, Level 2, 85 Park Road, Auckland, New Zealand.
Benjamin ThompsonLiggins Institute, University of Auckland, Building 503, Level 2, 85 Park Road, Auckland, New Zealand.
Jane E HardingLiggins Institute, University of Auckland, Building 503, Level 2, 85 Park Road, Auckland, New Zealand. j.harding@auckland.ac.nz.
Children with HYpoglycemia and Their Later Development (CHYLD) Study Team
University of Auckland · NZUniversity of British Columbia · CAUniversity of Waterloo · CAHong Kong Polytechnic University · HKUniversity of Canterbury · NZ

Funding

Children with Hypoglycemia and their Later Development (the CHYLD Study)R01HD069622 · NICHD · UNIVERSITY OF AUCKLAND · PI HARDING, JANE · 2011 to 2015
$1.7M
NICHD NIH HHS R01 HD069622
6 · The paper itself

Abstract

We aimed to investigate whether gestation at birth, birth weight, and head circumference at birth are still associated with brain volume and white matter microstructure at 9-10 years in children born late-preterm and at term. One hundred and eleven children born at ≥ 36 weeks gestation from the CHYLD Study cohort underwent brain magnetic resonance imaging at 9 to 10 years. Images were analysed using FreeSurfer for volumetric data and tract-based spatial statistics for diffusion data. Of the cohort, 101 children were included for volumetric analysis [boys, 49(49%); median age, 9.5 (range: 8.9-12.4) years]. Shorter gestation at birth, lower birthweight, and smaller birth head circumference were associated with smaller brain volumes at 9 to 10 years, both globally and regionally. Amongst the perinatal factors studied, head circumference at birth was the strongest predictor of later brain volumes. Gestation at birth and absolute birthweight were not associated with diffusion metrics of white matter skeleton. However, lower birthweight z-score was associated with higher fractional anisotropy and lower radial diffusivity. Our findings suggest that even in children born late preterm and at term, growth before birth and timing of birth are still associated with brain development in mid-childhood.

Indexed as

Diffusion Tensor ImagingWhite MatterBirth WeightBrainChildDiffusion Magnetic Resonance ImagingFemaleHumansInfant, NewbornMalePregnancy

Identifiers

PMID37528153
PMCPMC10393952
OpenAlexW4385457478

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.