Evidence map›Paper›PMID 37527925›Full record

ArticleeNeuro2023

Sources of Calcium at Connexin 36 Gap Junctions in the Retina.

Yuan-Hao Lee, W Wade Kothmann, Ya-Ping Lin, Alice Z Chuang, Jeffrey S Diamond, John O'Brien

Open access · goldAbstract read
In one paragraph

Article in eNeuro, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yuan-Hao LeeRichard S. Ruiz, Department of Ophthalmology and Visual Science, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030.
W Wade KothmannSynaptic Physiology Section, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland 20892.
Ya-Ping LinRichard S. Ruiz, Department of Ophthalmology and Visual Science, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030.
Alice Z ChuangRichard S. Ruiz, Department of Ophthalmology and Visual Science, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030.
Jeffrey S DiamondSynaptic Physiology Section, National Institute of Neurological Diseases and Stroke, Bethesda, Maryland 20892.ORCID 0000-0002-1770-2629
John O'BrienRichard S. Ruiz, Department of Ophthalmology and Visual Science, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030 jobrien3@UH.edu.ORCID 0000-0002-0270-3442
The University of Texas Health Science Center · USNational Institute of Neurological Disorders and Stroke · USThe University of Texas MD Anderson Cancer Center · US

Funding

Synaptic Mechanisms in the Mammalian RetinaZIANS003039 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI DIAMOND, JEFFREY S · 2009 to 2025
$24.5M
REGULATION OF RETINAL GAP JUNCTIONSR01EY012857 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI JOHN O'BRIEN · 2000 to 2026
$8.3M
UTHouston Core Center for Vision ResearchP30EY028102 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MASSEY, STEPHEN C · 2017 to 2021
$3.1M
Intramural NIH HHS ZIA NS003039NEI NIH HHS P30 EY028102NEI NIH HHS R01 EY012857
6 · The paper itself

Abstract

Synaptic plasticity is a fundamental feature of the CNS that controls the magnitude of signal transmission between communicating cells. Many electrical synapses exhibit substantial plasticity that modulates the degree of coupling within groups of neurons, alters the fidelity of signal transmission, or even reconfigures functional circuits. In several known examples, such plasticity depends on calcium and is associated with neuronal activity. Calcium-driven signaling is known to promote potentiation of electrical synapses in fish Mauthner cells, mammalian retinal AII amacrine cells, and inferior olive neurons, and to promote depression in thalamic reticular neurons. To measure local calcium dynamics

Indexed as

CalciumGap JunctionsAmacrine CellsAnimalsConnexinsGap Junction delta-2 ProteinMammalsMiceRetinaCalciumConnexinsGap Junction delta-2 ProteincalciumConnexin 36electrical synapseretinaSRRF

Identifiers

PMID37527925
PMCPMC10450809
OpenAlexW4385444172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.