Evidence map›Paper›PMID 37527891›Full record

SynthesisBMJ open2023

Effect of dexmedetomidine on postoperative nausea and vomiting in patients under general anaesthesia: an updated meta-analysis of randomised controlled trials.

Weihong Zhao, Jianli Li, Na Wang, Zhibin Wang, Meng Zhang, Huanhuan Zhang, Meinv Liu, Jinhua He, Dongdong Yu

Open access · goldAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 7 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 7 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Weihong ZhaoDepartment of Anesthesiology, Hebei General Hospital, Shijiazhuang, Hebei Province, China.
Jianli LiDepartment of Anesthesiology, Hebei General Hospital, Shijiazhuang, Hebei Province, China hblijianli@163.com.ORCID 0000-0001-6867-7825
Na WangDepartment of Rheumatology, Hebei General Hospital, Shijiazhuang, Hebei Province, China.
Zhibin WangDepartment of Anesthesiology, The Fifth People's Hospital of Hengshui, Hengshui, Hebei Province, China.
Meng ZhangDepartment of Anesthesiology, Hebei General Hospital, Shijiazhuang, Hebei Province, China.
Huanhuan ZhangDepartment of Anesthesiology, Hebei General Hospital, Shijiazhuang, Hebei Province, China.
Meinv LiuDepartment of Anesthesiology, Hebei General Hospital, Shijiazhuang, Hebei Province, China.
Jinhua HeDepartment of Anesthesiology, Hebei General Hospital, Shijiazhuang, Hebei Province, China.
Dongdong YuDepartment of Anesthesiology, Hebei General Hospital, Shijiazhuang, Hebei Province, China.
Hebei General Hospital · CNHengshui University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo explore the effect of dexmedetomidine (DEX) on postoperative nausea and vomiting (PONV) in adult patients after general anaesthesia.

designSystematic review and meta-analysis. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Randomised controlled trials (RCTs) comparing the efficacy of DEX with placebo or a single drug on PONV in adult patients after general anaesthesia. DATA SOURCES: We searched the PubMed, the Web of Science, the Cochrane Library and Embase (1 January 2000 to 30 June 2022) to select the relevant RCTs. DATA ANALYSIS: All the relevant data were analysed by using RevMan V.5.4. Heterogeneity was tested for each outcome, and random-effect or fixed-effect models was selected according to the level of heterogeneity. The primary outcome was the incidence of PONV. The secondary outcomes were the incidence of bradycardia, perioperative opioid consumption, extubation time and the length of hospitalisation.

resultsA total of 18 trials involving 2018 patients were included in this meta-analysis. Notably, 15 updated studies were not involved in the previous meta-analysis. The incidence of PONV in DEX group was lower than that in the control group (OR=0.49, 95% CI: 0.36 to 0.67) and the perioperative opioid consumption in DEX group was also decreased significantly (standard mean difference (SMD)=-1.04, 95% CI: -1.53 to -0.54). Moreover, the length of hospitalisation (SMD=-2.29, 95% CI: -4.31 to -0.28) and the extubation time (SMD=-0.75, 95% CI: -1.26 to -0.25) in DEX group were shorter. Whereas, more number of patients receiving DEX might increase the occurrence of bradycardia (OR=1.60, 95% CI: 1.13 to 2.27).

conclusionsDEX could decrease the occurrence of PONV in adult patients under general anaesthesia and promote the recovery after surgery. However, DEX might increase the occurrence of bradycardia. PROSPERO REGISTRATION NUMBER: CRD 42022341548.

Indexed as

DexmedetomidinePostoperative Nausea and VomitingAdultAnalgesics, OpioidAnesthesia, GeneralBradycardiaHumansAnalgesics, OpioidDexmedetomidineadult anaesthesiaadult surgeryadverse eventsanaesthetics

Identifiers

PMID37527891
PMCPMC10394554
OpenAlexW4385453818

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.