Evidence map›Paper›PMID 37527697›Full record

ArticleBone2023

Toward the use of MRI measurements of bound and pore water in fracture risk assessment.

Jeffry S Nyman, Thammathida Ketsiri, Elizabeth A Louie, Kevin D Harkins, Mary Kate Manhard, Daniel F Gochberg, Donald H Lee, Mihir J Desai, Jed Maslow, S Bobo Tanner and 1 more

Open access · greenAbstract read
In one paragraph

Article in Bone, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Bone health: Quality versus quantity.Journal of the Pediatric Orthopaedic Society of North America · 2024
    Article
  5. In Vivo Assessment of Bone Quality Without X-rays.Current osteoporosis reports · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jeffry S NymanDepartment of Orthopaedic Surgery, Vanderbilt University Medical Center, 1215 21st Ave. S., Suite 4200, Nashville, TN 37232, USA; Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN 37232, USA; Department of Veterans Affairs, Tennessee Valley Healthcare System, 1310 24th Ave. S., Nashville, TN 37212, USA; Vanderbilt Center for Bone Biology, Vanderbilt University Medical Center,1211 Medical Center Dr., Nashville, TN 37212, USA. Electronic address: jeffry.s.nyman@vumc.org.
Thammathida KetsiriDepartment of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN 37232, USA; Institute of Imaging Science, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN 37232, USA.
Elizabeth A LouieInstitute of Imaging Science, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN 37232, USA.
Kevin D HarkinsDepartment of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN 37232, USA; Institute of Imaging Science, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN 37232, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN 37232, USA.
Mary Kate ManhardImaging Research Center, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA.
Daniel F GochbergInstitute of Imaging Science, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN 37232, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN 37232, USA.
Donald H LeeDepartment of Orthopaedic Surgery, Vanderbilt University Medical Center, 1215 21st Ave. S., Suite 4200, Nashville, TN 37232, USA.
Mihir J DesaiDepartment of Orthopaedic Surgery, Vanderbilt University Medical Center, 1215 21st Ave. S., Suite 4200, Nashville, TN 37232, USA.
Jed MaslowDepartment of Orthopaedic Surgery, Vanderbilt University Medical Center, 1215 21st Ave. S., Suite 4200, Nashville, TN 37232, USA.
S Bobo TannerVanderbilt Center for Bone Biology, Vanderbilt University Medical Center,1211 Medical Center Dr., Nashville, TN 37212, USA; Department of Medicine, Division of Rheumatology, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN 37232, USA.
Mark D DoesDepartment of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN 37232, USA; Institute of Imaging Science, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN 37232, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN 37232, USA; Department of Electrical Engineering and Computer Science, Vanderbilt University, 400 24th Ave. S., Nashville, TN 37212, USA. Electronic address: mark.does@vanderbilt.edu.
Vanderbilt University Medical Center · USVanderbilt University · USCincinnati Children's Hospital Medical Center · US

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Bone Fracture Risk Assessment Through Bound - and Pore - Water MRIR01EB014308 · NIBIB · VANDERBILT UNIVERSITY · PI DOES, MARK D · 2012 to 2020
$3.2M
Diabetes-Related Changes Affecting Bone QualityI01BX004297 · VA · VETERANS HEALTH ADMINISTRATION · PI NYMAN, JEFFRY STEPHEN · 2019 to 2023
–
BLRD VA I01 BX004297NCATS NIH HHS UL1 TR002243NIBIB NIH HHS R01 EB014308
6 · The paper itself

Abstract

The current clinical assessment of fracture risk lacks information about the inherent quality of a person's bone tissue. Working toward an imaging-based approach to quantify both a bone tissue quality marker (tissue hydration as water bound to the matrix) and a bone microstructure marker (porosity as water in pores), we hypothesized that the concentrations of bound water (C

Indexed as

Fractures, BoneOsteoporosisAdultBayes TheoremBone DensityFemaleHumansMagnetic Resonance ImagingRisk AssessmentWaterWaterBound waterFractureMRIOsteoporosisPore waterUTE

Identifiers

PMID37527697
PMCPMC10528882
OpenAlexW4385386860

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.