ArticleEuropean journal of preventive cardiology2024
Echocardiographic heart ageing patterns predict cardiovascular and non-cardiovascular events and reflect biological age: the SardiNIA study.
Article in European journal of preventive cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Longitudinal biological aging trajectories and incident urolithiasis: a causal mediation analysis role of metabolic dysfunction in a large Chinese cohort.Frontiers in endocrinology · 2026Article
- Mismatch between echocardiography-predicted cardiac age and chronologic age: insights from the multi-ethnic study of atherosclerosis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Association of the dietary inflammatory index with multi-organ biological age acceleration.Journal of health, population, and nutrition · 2025Article
- AI assisted focused cardiac ultrasound in preventive cardiology - a perspective.NPJ cardiovascular health · 2025Review
- Cardiovascular magnetic resonance imaging markers of ageing: a multi-centre, cross-sectional cohort study.European heart journal open · 2025Article
- Explainable AI associates ECG aging effects with increased cardiovascular risk in a longitudinal population study.NPJ digital medicine · 2025Article
- Biological heart and brain ageing in subjects with cardiovascular diseases.Frontiers in cardiovascular medicine · 2025Article
- Cardiovascular Aging and Risk Assessment: How Multimodality Imaging Can Help.Diagnostics (Basel, Switzerland) · 2024Review
- EchoAGE: Echocardiography-based Neural Network Model Forecasting Heart Biological Age.Aging and disease · 2024Article
- Vasculopathy Augments Cardiovascular Risk in Community-Dwelling Elderly with Left Ventricular Hypertrophy.Journal of personalized medicine · 2024Article
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18 authors at 6 institutions in 2 countries.
Funding
Abstract
aimsAge is a crucial risk factor for cardiovascular (CV) and non-CV diseases. As people age at different rates, the concept of biological age has been introduced as a personalized measure of functional deterioration. Associations of age with echocardiographic quantitative traits were analysed to assess different heart ageing rates and their ability to predict outcomes and reflect biological age. METHODS AND
resultsAssociations of age with left ventricular mass, geometry, diastolic function, left atrial volume, and aortic root size were measured in 2614 healthy subjects. Based on the 95% two-sided tolerance intervals of each correlation, three discrete ageing trajectories were identified and categorized as 'slow', 'normal', and 'accelerated' heart ageing patterns. The primary endpoint included fatal and non-fatal CV events, and the secondary endpoint was a composite of CV and non-CV events and all-cause death. The phenotypic age of the heart (HeartPhAge) was estimated as a proxy of biological age. The slow ageing pattern was found in 8.7% of healthy participants, the normal pattern in 76.9%, and the accelerated pattern in 14.4%. Kaplan-Meier curves of the heart ageing patterns diverged significantly (P = 0.0001) for both primary and secondary endpoints, with the event rate being lowest in the slow, intermediate in the normal, and highest in the accelerated pattern. In the Cox proportional hazards model, heart ageing patterns predicted both primary (P = 0.01) and secondary (P = 0.03 to <0.0001) endpoints, independent of chronological age and risk factors. Compared with chronological age, HeartPhAge was 9 years younger in slow, 4 years older in accelerated (both P < 0.0001), and overlapping in normal ageing patterns.
conclusionStandard Doppler echocardiography detects slow, normal, and accelerated heart ageing patterns. They predict CV and non-CV events, reflect biological age, and provide a new tool to calibrate prevention timing and intensity.
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