Evidence map›Paper›PMID 37527452›Full record

Observational studyNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco2024

Identification of Sociodemographic, Clinical, and Genetic Factors to Aid Alaska Native and American Indian People to Successfully Quit Smoking.

Jaedon P Avey, Krista R Schaefer, Carolyn J Noonan, Susan B Trinidad, Clemma J Muller, Katrina G Claw, Denise A Dillard, Michael R Todd, Julie A Beans, Rachel F Tyndale and 2 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Jaedon P AveyResearch Department, Southcentral Foundation, Anchorage, AK, USA.ORCID 0000-0002-3858-0595
Krista R SchaeferResearch Department, Southcentral Foundation, Anchorage, AK, USA.ORCID 0000-0001-5300-1558
Carolyn J NoonanInstitute for Research and Education to Advance Community Health, Washington State University, Seattle, WA, USA.
Susan B TrinidadDepartment of Bioethics and Humanities, University of Washington, Seattle, WA, USA.
Clemma J MullerInstitute for Research and Education to Advance Community Health, Washington State University, Seattle, WA, USA.
Katrina G ClawDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Denise A DillardResearch Department, Southcentral Foundation, Anchorage, AK, USA.
Michael R ToddResearch Department, Southcentral Foundation, Anchorage, AK, USA.
Julie A BeansResearch Department, Southcentral Foundation, Anchorage, AK, USA.
Rachel F TyndaleCentre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.ORCID 0000-0003-1297-2053
Renee F RobinsonDepartment of Pharmacy, Idaho State University, Pocatello, ID; University of Alaska Anchorage, Anchorage, AK, USA.
Kenneth E ThummelDepartment of Pharmaceutics, University of Washington, Seattle, WA, USA.
Southcentral Foundation · USUniversity of Washington · USWashington State University · USCentre for Addiction and Mental Health · CAIdaho State University · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Researcher Career Enhancement ProjectS06GM142122 · NIGMS · SOUTHCENTRAL FOUNDATION · PI MICHLIG, GEORGIA J · 2021 to 2024
$3.9M
Population-based Interventions to Improve Behavioral Health in a Tribal Healthcare SystemS06GM123545 · NIGMS · SOUTHCENTRAL FOUNDATION · PI DILLARD, DENISE A · 2017 to 2020
$1.6M
NIGMS NIH HHS S06 GM123545NIGMS NIH HHS S06 GM142122
6 · The paper itself

Abstract

introductionAlaska Native and American Indian (ANAI) people have a smoking prevalence of 23%. Nicotine metabolite ratio (NMR) and genetic testing may enable tailored selection of tobacco cessation medication. AIMS AND

methodsThe purpose of this study was to evaluate the relative contributions of NMR, cessation medication, demographics, and tobacco use history to cessation. Participants were recruited into an observational cohort study consisting of a baseline visit prior to their quit date and 6-week follow-up. Demographic and tobacco use surveys and blood, urine, and breath samples were collected at each visit. Electronic health records were queried for cessation medications. NMR was categorized into slow or normal nicotine metabolism phenotypes (<0.31 and ≥ 0.31, respectively). The main outcome was cessation at 6 weeks. Analyses consisted of descriptive statistics, medication and phenotype concordance, and estimates of relative risk (RR) of quitting.

resultsWe enrolled 151 ANAI adults who smoked cigarettes daily. Two-thirds had normal nicotine metabolism phenotype. Retrospective medication and phenotype concordance was 39%. The overall quit rate was 25%. No demographic factors or tobacco use history were associated with quit success. Varenicline and bupropion increased the likelihood of quitting (RR = 2.93 [1.42, 6.03] and RR = 2.52 [1.12, 5.64], respectively) compared to nicotine replacement therapy. Non-optimal medication and phenotype concordance decreased likelihood of quit success (RR = 0.44 [0.22, 0.91]) compared to optimal concordance.

conclusionsThis exploratory study found associations between quit success and tobacco cessation medication as well as medication and phenotype concordance. Additional research is needed to assess use of NMR for treatment selection among ANAI people. IMPLICATIONS: These results broadly support additional community-engaged research to improve medication and phenotype concordance in tribal health settings. Such future research on implementing meditcation and phenotype concordance holds promise to improve expectations, quit success, and health outcomes amongst individuals attempting to quit smoking.

Indexed as

Smoking CessationSociodemographic FactorsAdultAmerican Indian or Alaska NativeHumansNicotineNicotinic AgonistsRetrospective StudiesSmokingTobacco Use Cessation DevicesNicotineNicotinic Agonists

Identifiers

PMID37527452
PMCPMC10734384
OpenAlexW4385450414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.