Evidence map›Paper›PMID 37527424›Full record

Trial reportTherapeutic hypothermia and temperature management2023

Core Warming of Coronavirus Disease 2019 Patients Undergoing Mechanical Ventilation: A Pilot Study.

Nathaniel P Bonfanti, Nicholas M Mohr, David C Willms, Roger J Bedimo, Emily Gundert, Kristina L Goff, Erik B Kulstad, Anne M Drewry

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Therapeutic hypothermia and temperature management, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Sepsis in the absence of fever: Determining the criteria for and feasibility of future therapeutic temperature management trials.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Nathaniel P BonfantiDepartment of Emergency Medicine, University of Texas at Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-9564-9536
Nicholas M MohrDepartment of Emergency Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
David C WillmsDepartment of Critical Care, Sharp Memorial Hospital, San Diego, California, USA.
Roger J BedimoDepartment of Internal Medicine, Division of Infectious Disease, VA North Texas Health Care System and University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Emily GundertDepartment of Emergency Medicine, University of Texas at Southwestern Medical Center, Dallas, Texas, USA.
Kristina L GoffDepartment of Anesthesiology, University of Texas at Southwestern Medical Center, Dallas, Texas, USA.
Erik B KulstadDepartment of Emergency Medicine, University of Texas at Southwestern Medical Center, Dallas, Texas, USA.
Anne M DrewryDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA.
The University of Texas Southwestern Medical Center · USSharp Memorial Hospital · USUniversity of Iowa · USVA North Texas Health Care System · USWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fever is a recognized protective factor in patients with sepsis, and growing data suggest beneficial effects on outcomes in sepsis with elevated temperature, with a recent pilot randomized controlled trial (RCT) showing lower mortality by warming afebrile sepsis patients in the intensive care unit (ICU). The objective of this prospective single-site RCT was to determine if core warming improves respiratory physiology of mechanically ventilated patients with coronavirus disease 2019 (COVID-19), allowing earlier weaning from ventilation, and greater overall survival. A total of 19 patients with mean age of 60.5 (±12.5) years, 37% female, mean weight 95.1 (±18.6) kg, and mean body mass index 34.5 (±5.9) kg/m

Indexed as

COVID-19Hypothermia, InducedSepsisFemaleHumansMaleMiddle AgedOxygenPilot ProjectsRespiration, ArtificialOxygenCOVID-19esophageal warminginduced hyperthermiarespiratory insufficiencysepsisvirus replication

Identifiers

PMID37527424
PMCPMC10698775
OpenAlexW4385444281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.