Evidence map›Paper›PMID 37526867›Full record

ReviewNeurochemical research2023

Research Progress of Antioxidants in Oxidative Stress Therapy after Spinal Cord Injury.

Can Zhang, Tianyu Zhai, Jinghui Zhu, Dongmin Wei, Shuting Ren, Yanling Yang, Feng Gao, Lin Zhao

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurochemical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Spinal Cord Injury Remyelination: Pathways to Therapies.International journal of molecular sciences · 2025
    Review
  7. Ferroptosis: a new target for depression prevention and treatment.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Can ZhangMedical School of Yan'an University, No. 580 Shengdi Road, Baota District, Yan'an, 716000, Shaanxi, China.
Tianyu ZhaiMedical School of Yan'an University, No. 580 Shengdi Road, Baota District, Yan'an, 716000, Shaanxi, China.
Jinghui ZhuMedical School of Yan'an University, No. 580 Shengdi Road, Baota District, Yan'an, 716000, Shaanxi, China.
Dongmin WeiMedical School of Yan'an University, No. 580 Shengdi Road, Baota District, Yan'an, 716000, Shaanxi, China.
Shuting RenMedical School of Yan'an University, No. 580 Shengdi Road, Baota District, Yan'an, 716000, Shaanxi, China.
Yanling YangMedical School of Yan'an University, No. 580 Shengdi Road, Baota District, Yan'an, 716000, Shaanxi, China.
Feng GaoMedical School of Yan'an University, No. 580 Shengdi Road, Baota District, Yan'an, 716000, Shaanxi, China.
Lin ZhaoMedical School of Yan'an University, No. 580 Shengdi Road, Baota District, Yan'an, 716000, Shaanxi, China. jkpzhaolin@163.com.
Yan'an University · CN

Funding

Shaanxi Social Development of Science and Technology Project 2021SF-082This study was supported by National Natural Science Foundation of China 81641048
6 · The paper itself

Abstract

Spinal cord injury (SCI) is a serious problem in the central nervous system resulting in high disability and mortality with complex pathophysiological mechanisms. Oxidative stress is one of the main secondary reactions of SCI, and its main pathophysiological marker is the production of excess reactive oxygen species. The overproduction of reactive oxygen species and insufficient antioxidant capacity lead to the occurrence of oxidative stress and neuroinflammation, and the dysregulation of oxidative stress and neuroinflammation leads to further aggravation of damage. Oxidative stress can initiate a variety of inflammatory and apoptotic pathways, and targeted antioxidant therapy can greatly reduce oxidative stress and reduce neuroinflammation, which has a certain positive effect on rehabilitation and prognosis in SCI. This article reviewed the research on different types of antioxidants and related treatments in SCI, focusing on the mechanisms of oxidative stress.

Indexed as

AntioxidantsSpinal Cord InjuriesHumansNeuroinflammatory DiseasesOxidative StressReactive Oxygen SpeciesSpinal CordAntioxidantsReactive Oxygen SpeciesAntioxidantsLipid peroxidationMitochondrial damageOxidative stressSpinal cord injury

Identifiers

PMID37526867
OpenAlexW4385442023

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.