Evidence map›Paper›PMID 37526752›Full record

Trial reportAnnals of surgical oncology2023

A Randomized Single-Blinded Study Comparing Preoperative with Post-Mastectomy PECS Block for Post-operative Pain Management in Bilateral Mastectomy with Immediate Reconstruction.

Ingrid M Lizarraga, K Huang, B Yalamuru, S L Mott, Z A Sibenaller, J N Keith, S L Sugg, L M Erdahl, M Seering

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Annals of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03653988 (Analgesia Efficacy of Pre-operative and Post-operative PEC I/II Block for Bilateral Mastectomy With Reconstruction), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03653988 nacompletednot on this map

Analgesia Efficacy of Pre-operative and Post-operative PEC I/II Block for Bilateral Mastectomy With Reconstruction

TypeinterventionalSponsorMelinda SeeringRan2019 to 2021Enrolled34ConditionsBreast Cancer, Postoperative Pain, Anesthesia, Nerve BlockArmsPEC I/II blocks by anesthesiologist - pre-operative, PEC I/II blocks by surgeon - intra-operative
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ingrid M LizarragaDepartment of Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. ingrid-lizarraga@uiowa.edu.
K HuangDepartment of Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
B YalamuruPain Division, Department of Anesthesiology, University of Virginia, Charlottesville, VA, USA.
S L MottHolden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Z A SibenallerHolden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
J N KeithHolden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
S L SuggDepartment of Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
L M ErdahlDepartment of Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
M SeeringDepartment of Anesthesia, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
University of Iowa Hospitals and Clinics · USUniversity of Virginia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUltrasound-guided pectoralis muscle blocks (PECS I/II) are well established for postoperative pain control after mastectomy with reconstruction. However, optimal timing is unclear. We conducted a randomized controlled single-blinded single-institution trial comparing outcomes of block performed pre-incision versus post-mastectomy.

methodPatients with breast cancer undergoing bilateral mastectomy with immediate expander/implant reconstruction were randomized to receive ultrasound-guided PECS I/II either pre-incision (PreM, n = 17) or post-mastectomy and before reconstruction (PostM, n = 17). The primary outcome was the average pain score using the Numerical Rating Score during post-anesthesia care unit (PACU) and inpatient stay, with the study powered to detect a difference in mean pain score of 2. Secondary outcomes included mean pain scores on postoperative day (POD) 2, 3, 7, 14, 90, and 180; pain catastrophizing scores; narcotic requirements; PACU/inpatient length of stay; block procedure time; and complications.

resultNo significant differences between the two groups were noted in average pain score during PACU (p = 0.57) and 24-h inpatient stay (p = 0.33), in the 2 weeks after surgery at rest (p = 0.90) or during movement (p = 0.30), or at POD 90 and 180 at rest (p = 0.42) or during movement (p = 0.31). Median duration of block procedure (PreM 7 min versus PostM 6 min, p = 0.21) did not differ. Median PACU and inpatient length of stay were the same in each group. Inpatient narcotic requirements were similar, as were length of stay and post-surgical complication rates.

conclusionIntraoperative ultrasound-guided PECS I/II block administered by surgeons following mastectomy had similar outcomes to preoperative blocks.

trial registrationThis trial is registered with Clinical Research Information Service (NCT03653988).

Indexed as

Breast NeoplasmsNerve BlockAnalgesics, OpioidFemaleHumansMastectomyPostoperative PainAnalgesics, Opioid

Identifiers

PMID37526752
OpenAlexW4385442860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.