Evidence map›Paper›PMID 37526326›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Adipose METTL14-Elicited N

Qianqian Kang, Xiaorong Zhu, Decheng Ren, Alexander Ky, Ormond A MacDougald, Robert W O'Rourke, Liangyou Rui

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. The Role of NMedComm · 2026
    Review
  3. Review
  4. mInternational journal of molecular medicine · 2026
    Review
  5. Review
  6. Article
  7. POMC neuron METTL14/mNature communications · 2026
    Article
  8. Article
  9. Article
  10. NBiomolecules · 2026
    Review
  11. Article
  12. Review
  13. METTL14-Induced MAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  14. Article
  15. Review
  16. Review
  17. Divergent roles of mNature communications · 2025
    Article
  18. Article
  19. Unveiling the dynamics and therapeutic potential of mInternational journal of biological sciences · 2025
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Qianqian KangDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Xiaorong ZhuDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Decheng RenDepartment of Medicine, University of Chicago, Chicago, IL, 60637, USA.
Alexander KyDepartment of Surgery, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Ormond A MacDougaldDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Robert W O'RourkeDepartment of Surgery, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Liangyou RuiDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-8433-8137
University of Michigan · USBeijing Tongren Hospital · CNUniversity of Chicago · US

Funding

PUBLIC HEALTH DEMONSTRATIONP60DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MYERS, MARTIN G · 1985 to 2012
$26.5M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILEY, JOHN W · 1986 to 2021
$22.5M
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI GRAEME I BELL, Raghavendra G Mirmira · 2013 to 2026
$20.9M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joyce Lee · 2010 to 2026
$20.3M
Michigan Mouse Metabolic Phenotyping CenterU2CDK110768 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ELIAS, CAROL FUZETI · 2016 to 2021
$6.2M
The Role of Hypothalamic Slug in the Regulation of Leptin Sensitivity, Energy Balance, and Body WeightR01DK114220 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RUI, LIANGYOU · 2017 to 2024
$4.2M
Mechanisms of adipocyte loss in laminopathy-induced lipodystrophy in mice and humansR01DK125513 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ormond A MacDougald, Elif Arioglu Oral · 2020 to 2026
$3.0M
Role of adipose mRNA modifications in metabolic diseaseR01DK130111 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIANGYOU RUI · 2022 to 2026
$2.4M
Mechanisms by which adipocytes adapt to cool environmental temperaturesR01DK121759 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MACDOUGALD, ORMOND A · 2020 to 2024
$2.0M
Neural determinants on meal size in invertebrate models of obesityR01DK130875 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Monica Dus · 2022 to 2026
$1.7M
Role of hepatic Mettl14 pathways in liver metabolism and body metabolic homeostasisR01DK127568 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RUI, LIANGYOU · 2021 to 2023
$1.2M
CSRD VA I01 CX001811NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P30 DK034933NIDDK NIH HHS P30 DK089503NIDDK NIH HHS P60 DK020572NIDDK NIH HHS R01 DK114220NIDDK NIH HHS R01 DK121759NIDDK NIH HHS R01 DK125513NIDDK NIH HHS R01 DK127568NIDDK NIH HHS R01 DK130111NIDDK NIH HHS R01 DK130875NIDDK NIH HHS R56 DK125513NIDDK NIH HHS R56 DK132785NIDDK NIH HHS U2C DK110768NIH HHS
6 · The paper itself

Abstract

White adipose tissue (WAT) lipolysis releases free fatty acids as a key energy substance to support metabolism in fasting, cold exposure, and exercise. Atgl, in concert with Cgi-58, catalyzes the first lipolytic reaction. The sympathetic nervous system (SNS) stimulates lipolysis via neurotransmitter norepinephrine that activates adipocyte β adrenergic receptors (Adrb1-3). In obesity, adipose Adrb signaling and lipolysis are impaired, contributing to pathogenic WAT expansion; however, the underling mechanism remains poorly understood. Recent studies highlight importance of N

Indexed as

Insulin ResistanceNon-alcoholic Fatty Liver DiseaseAdrenergic AgentsAnimalsLipolysisMethyltransferasesMiceObesityRNAAdrenergic AgentsMethyltransferasesMettl14 protein, mouseRNAadipose tissuediabeteslipolysism6AobesityRNA modificationsβ-adrenergic signaling

Identifiers

PMID37526326
PMCPMC10558699
OpenAlexW4385442258

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.