ArticleOrthodontics & craniofacial research2023
Genetic and other factors contributing to external apical root resorption in orthodontic patients.
Article in Orthodontics & craniofacial research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 16 citations in OpenAlex.
- Randomised Clinical Trial on the Effect of Intermittent Vibrational Force Application During Orthodontic Treatment With Aligners on Root Resorption.Orthodontics & craniofacial research · 2025Trial
- A systems biology network analysis of root resorption biomarkers and their clinical relevance in orthodontics: a pilot study.Genomics & informatics · 2026Article
- Article
- Biomarkers for Treatment Response in Orthodontics: Molecular Mechanisms, Clinical Utility, and Future Directions.International journal of molecular sciences · 2026Review
- Cytokines as Key Drivers of Pathological Root Resorption: Integrating Molecular Mechanisms, Genetic Determinants, and Biomarker-Based Insights.Biomedicines · 2026Review
- Association between tooth agenesis and root morphology assessed by periapical radiographs : Retrospective cross-sectional observational study.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026Article
- Apical root resorption in Class III patients following pronounced mandibular incisor retraction with lingual high precision fixed appliances: a retrospective cohort study.Head & face medicine · 2026Article
- External Root Resorption Associated with Orthodontic Treatment-Descriptive Correlations of Biological and Dental Risk Factors.Dentistry journal · 2026Article
- Investigation of genetic polymorphisms associated with severe root resorption in orthodontic surgery patients.Brazilian dental journal · 2026Article
- Risk Factors Associated With Orthodontic Root Resorption and its Treatment Methods.Journal of pharmacy & bioallied sciences · 2025Review
- External apical root resorption assessment revisited: a scoping review.The Angle orthodontist · 2025Article
- The Influence of Orthodontic Treatment on Periodontal Health between Challenge and Synergy: A Narrative Review.Dentistry journal · 2024Review
- Effect of genetic factors on root resorption after orthodontic treatment: A systematic review.Bioinformation · 2024Article
- Bibliometric analysis of publications on genetic polymorphism and external apical root resorption research.Dental press journal of orthodontics · 2024Review
- External apical root resorption in African American orthodontic patients.European journal of orthodontics · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveExternal apical root resorption (EARR) is a multifactorial disorder with adverse clinical outcomes in orthodontic practices often resulting in significant root shortening. This study examined the effect that specific single nucleotide polymorphisms (SNPs) have on the risk of developing EARR in orthodontic patients in X. We also evaluated how other selected patient- and treatment-related factors may contribute to root resorption in these patients. SETTING/SAMPLE: Patients included in this case-control study were treated at the University of Alabama at Birmingham School of Dentistry, Department of Orthodontics.
methodsPanoramic radiographs were used to measure root resorption of the maxillary incisors. EARR was recorded when at least 20% of the root length had been lost with orthodontic treatment. Factors evaluated for association with EARR included ethnicity, sex, age, dental and skeletal classifications, ANB, U1-SN, overjet, treatment type and time, and SNPs in IL-1A (rs1800587), IL-1B (rs1143634), IL-1RN (rs419598), P2RX7 (rs1718119 and rs2230912), IRAK1 (rs1059703) and CASP1 (rs530537, rs580253 and rs554344). Chi-square test, Student's t test, Wilcoxon test, Benjamin-Hochberg false discovery rate (FDR) adjustment and logistic regression were used to analyse the data. The significance level was defined as P < .05.
resultsWe found that extraction treatment protocol and dental classification displayed significant association with root resorption. Furthermore, the GG genotype of IL-1A rs1800587 variant (in individuals with an increased overjet) predisposed Caucasians to EARR. While CASP1 (rs530537) variant may contribute to the risk of root resorption, it was not statistically significant after FDR adjustment (P = .09).
conclusionsBoth patient- and treatment-related factors contributed to EARR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.