Evidence map›Paper›PMID 37526031›Full record

ArticleMagnetic resonance in medicine2023

Initial feasibility and challenges of hyperpolarized

Neil J Stewart, Nara S Higano, Shanmukha Mukthapuram, Matthew M Willmering, Wolfgang Loew, Michael West, Anita Arnsperger, Ronald Pratt, Madhwesha R Rao, Rolf F Schulte and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Functional Pulmonary Imaging.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  5. Pulmonary MRI in Newborns and Children.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Neil J StewartCenter for Pulmonary Imaging Research, Pulmonary Medicine and Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0001-8358-394X
Nara S HiganoCenter for Pulmonary Imaging Research, Pulmonary Medicine and Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0002-6233-161X
Shanmukha MukthapuramDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Matthew M WillmeringCenter for Pulmonary Imaging Research, Pulmonary Medicine and Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0002-4356-9622
Wolfgang LoewDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Michael WestCenter for Pulmonary Imaging Research, Pulmonary Medicine and Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Anita ArnspergerDivision of Respiratory Care, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Ronald PrattDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Madhwesha R RaoPOLARIS, Imaging Sciences, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK.
Rolf F SchulteGE Healthcare, Munich, Germany.
Jim M WildPOLARIS, Imaging Sciences, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK.ORCID 0000-0002-7246-8660
Jason C WoodsCenter for Pulmonary Imaging Research, Pulmonary Medicine and Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0002-8080-7511
Cincinnati Children's Hospital Medical Center · USUniversity of Sheffield · GBSiemens Healthineers (Germany) · DE

Funding

Pulmonary Development and Disease Pathogenesis Training ProgramT32HL007752 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Francis Xavier McCormack, Anne-Karina Theresia Perl · 1994 to 2026
$6.3M
MRI Phenotyping of Severe BPD and Prediction of OutcomesR01HL146689 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI JASON C WOODS · 2019 to 2026
$4.6M
Medical Research Council MR/M008894/1NHLBI NIH HHS R01 HL146689NHLBI NIH HHS T32 HL007752
6 · The paper itself

Abstract

purposeThe underlying functional and microstructural lung disease in neonates who are born preterm (bronchopulmonary dysplasia, BPD) remains poorly characterized. Moreover, there is a lack of suitable techniques to reliably assess lung function in this population. Here, we report our preliminary experience with hyperpolarized

methodsNeonatal intensive care patients with established BPD were recruited (N = 9) and imaged at a corrected gestational age of median:40.7 (range:37.1, 44.4) wk using a 1.5T neonatal scanner. 2D

resultsSpiral-based

conclusionWe have demonstrated initial feasibility of

Indexed as

Bronchopulmonary DysplasiaAdultChildFeasibility StudiesHumansInfant, NewbornLungMagnetic Resonance ImagingXenon IsotopesXenon Isotopesbronchopulmonary dysplasiahyperpolarized 129Xelung MRIneonatal MRI

Identifiers

PMID37526031
PMCPMC10629838
OpenAlexW4385442865

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.