Rapid, green disulphide bond formation in water using the corrin dicyanocobinamide.

Alyssa Spear, Oleksandr Orativskyi, Samantha Tran, Jon A Zubieta, Robert P Doyle

Abstract read

In one paragraph

Article in Chemical communications (Cambridge, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Corrin Ring Modification in Peptide Drug Development - a Brief History of "Corrination".ChemMedChem · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alyssa SpearDepartment of Chemistry, Syracuse University, Syracuse, New York 13244, USA. rpdoyle@syr.edu.ORCID http://orcid.org/0000-0001-6549-8311

Oleksandr OrativskyiDepartment of Chemistry, Syracuse University, Syracuse, New York 13244, USA. rpdoyle@syr.edu.

Samantha TranDepartment of Chemistry, Syracuse University, Syracuse, New York 13244, USA. rpdoyle@syr.edu.ORCID http://orcid.org/0009-0007-8183-3977

Jon A ZubietaDepartment of Chemistry, Syracuse University, Syracuse, New York 13244, USA. rpdoyle@syr.edu.

Robert P DoyleDepartment of Chemistry, Syracuse University, Syracuse, New York 13244, USA. rpdoyle@syr.edu.ORCID http://orcid.org/0000-0001-6786-5656

Funding

Second generation GLP-1 agonists without nausea/emesis side effectsR01DK128443 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI DE JONGHE, BART C, DOYLE, ROBERT P · 2021 to 2024

$2.4M

NIDDK NIH HHS R01 DK128443

6 · The paper itself

Abstract

Peptide chemists seek rapid methods combined with facile purification when producing disulphide bonds post solid-phase synthesis. Current methods typically require long reaction times of up to two days, can result in side-products from over-oxidation and/or degradation, require organic solvents, and/or require challenging purification. Herein, we describe a rapid, green, and facile oxidation of a series of peptides with up to three disulphide bonds. The method was conducted in aqueous solution, in air, utilizing the biocompatible corrin ring-containing compound dicyanocobinamide, and offers reaction times under 1 hour with simple one step removal of the catalyst.

Indexed as

DisulfidesWaterCorrinoidsNitrilesOrganometallic CompoundsPeptidescorrinCorrinoidsdicyanocobinamideDisulfidesNitrilesOrganometallic CompoundsPeptidesWater

Identifiers

PMID37525990

DOI10.1039/d3cc02646a

PMCPMC10445360

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.