ArticleCNS neuroscience & therapeutics2024
Acoustic-electric trigeminal-nerve stimulation enhances functional connectivity in patients with disorders of consciousness.
Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Trigeminal nerve stimulation as a neuromodulatory approach for disorders of consciousness.Neural regeneration research · 2026Article
- Cortical processing modulation in DOC by preferred music-coupled 40 Hz binaural stimulation: an exploratory EEG-fNIRS study.Frontiers in psychology · 2026Article
- Neural mechanism of trigeminal nerve stimulation recovering defensive arousal responses in traumatic brain injury.Theranostics · 2025Article
- Discriminative power of diverse nonlinear EEG dynamics across consciousness states during auditory stimulation in disorders of consciousness.Frontiers in human neuroscience · 2025Article
- External trigeminal nerve stimulation for neuropsychiatric disorders: mechanisms, efficacy, and future directions.Frontiers in neurology · 2025Review
- Acoustic-electric trigeminal-nerve stimulation enhances functional connectivity in patients with disorders of consciousness.CNS neuroscience & therapeutics · 2024Article
- Progress in non-invasive neuromodulation based on consciousness-related neural circuits: a narrative review.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
aimDisruption of functional brain connectivity is thought to underlie disorders of consciousness (DOC) and recovery of impaired connectivity is suggested as an indicator of consciousness restoration. We recently found that rhythmic acoustic-electric trigeminal-nerve stimulation (i.e., musical stimulation synchronized to electrical stimulation of the trigeminal nerve) in the gamma band can improve consciousness in patients with DOC. Here, we investigated whether these beneficial stimulation effects are mediated by alterations in functional connectivity.
methodsSixty-three patients with DOC underwent 5 days of gamma, beta, or sham acoustic-electric trigeminal-nerve stimulation. Resting-state electroencephalography was measured before and after the stimulation and functional connectivity was assessed using phase-lag index (PLI).
resultsWe found that gamma stimulation induces an increase in gamma-band PLI. Further characterization revealed that the enhancing effect is (i) specific to the gamma band (as we observed no comparable change in beta-band PLI and no effect of beta-band acoustic-electric stimulation or sham stimulation), (ii) widely spread across the cortex, and (iii) accompanied by improvements in patients' auditory abilities.
conclusionThese findings show that gamma acoustic-electric trigeminal-nerve stimulation can improve resting-state functional connectivity in the gamma band, which in turn may be linked to auditory abilities and/or consciousness restoration in DOC patients.
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Registered trials
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