Evidence map›Paper›PMID 37525300›Full record

ArticleMilitary Medical Research2023

The marriage of immunomodulatory, angiogenic, and osteogenic capabilities in a piezoelectric hydrogel tissue engineering scaffold for military medicine.

Ping Wu, Lin Shen, Hui-Fan Liu, Xiang-Hui Zou, Juan Zhao, Yu Huang, Yu-Fan Zhu, Zhao-Yu Li, Chao Xu, Li-Hua Luo and 5 more

Abstract read
In one paragraph

Article in Military Medical Research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed.

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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ping Wu *Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, Zhejiang, China.
Lin Shen *Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, Zhejiang, China.
Hui-Fan Liu *Department of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Xiang-Hui Zou *National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Juan ZhaoKey Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, Zhejiang, China.
Yu HuangKey Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, Zhejiang, China.
Yu-Fan ZhuDepartment of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Zhao-Yu LiDepartment of Overseas Education College, Jimei University, Xiamen, 361021, Fujian, China.
Chao XuNational Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Li-Hua LuoSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Zhi-Qiang LuoNational Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Min-Hao WuDepartment of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. wuminhao1991@whu.edu.cn.
Lin CaiDepartment of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. orthopedics@whu.edu.cn.
Xiao-Kun LiOujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China. xiaokunli@wmu.edu.cn.
Zhou-Guang WangKey Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, Zhejiang, China. wzhouguang@gmail.com.ORCID 0000-0001-7374-6506

Funding

National Natural Science Foundation of China 82202352National Natural Science Foundation of China 82271629Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University ZNLH202202Wenzhou Medical University grant QTJ23004
6 · The paper itself

Abstract

backgroundMost bone-related injuries to grassroots troops are caused by training or accidental injuries. To establish preventive measures to reduce all kinds of trauma and improve the combat effectiveness of grassroots troops, it is imperative to develop new strategies and scaffolds to promote bone regeneration.

methodsIn this study, a porous piezoelectric hydrogel bone scaffold was fabricated by incorporating polydopamine (PDA)-modified ceramic hydroxyapatite (PDA-hydroxyapatite, PHA) and PDA-modified barium titanate (PDA-BaTiO

resultsThe incorporation of BaTiO

conclusionThe piezoelectric Cs/Gel/PHA/PBT hydrogels developed here with favorable immunomodulation, angiogenesis, and osteogenesis functions may be used as a substitute in periosteum injuries, thereby offering the novel strategy of applying piezoelectric stimulation in bone tissue engineering for the enhancement of combat effectiveness in grassroots troops.

Indexed as

ChitosanMilitary MedicineAnimalsBarium CompoundsBiocompatible MaterialsHumansHuman Umbilical Vein Endothelial CellsHydrogelsHydroxyapatitesOsteogenesisPhosphatidylinositol 3-KinasesRatsTissue EngineeringTitaniumBarium Compoundsbarium titanate(IV)Biocompatible MaterialsChitosanHydrogelsHydroxyapatitesPhosphatidylinositol 3-KinasesTitaniumAngiogenesisImmunomodulationOsteogenic differentiationPiezoelectric hydrogelTissue engineering scaffold

Identifiers

PMID37525300
PMCPMC10388535

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.