Evidence map›Paper›PMID 37525265›Full record

ArticleAdvances in rheumatology (London, England)2023

Mesenchymal stem cells modulate IL-17 and IL-9 production induced by Th17-inducing cytokine conditions in autoimmune arthritis: an explorative analysis.

Maximilian Riekert, Giovanni Almanzar, Marc Schmalzing, Norbert Schütze, Franz Jakob, Martina Prelog

Open access · diamondAbstract read
PubMed Publisher
In one paragraph

Article in Advances in rheumatology (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Maximilian RiekertDepartment of Pediatrics, University Hospital Wuerzburg, Wuerzburg, Germany. max.riekert@web.de.ORCID 0000-0002-5606-7883
Giovanni AlmanzarDepartment of Pediatrics, University Hospital Wuerzburg, Wuerzburg, Germany.
Marc SchmalzingDepartment of Internal Medicine II, University Hospital of Wuerzburg, Wuerzburg, Germany.
Norbert SchützeOrthopedic Clinic, Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Wuerzburg, Germany.
Franz JakobOrthopedic Clinic, Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Wuerzburg, Germany.
Martina PrelogDepartment of Pediatrics, University Hospital Wuerzburg, Wuerzburg, Germany.
Universitätsklinikum Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe importance of proinflammatory T-cells and their cytokine production in patients with autoimmune arthritis has been widely described. Due to their immunomodulatory properties, mesenchymal stem cells (MSCs) have come into focus as a potential therapeutic concept. The aim of this study was to investigate the influence of MSCs on the phenotype, cytokine profile, and functionality of naive and non-naive CD4

methodsMagnetically isolated naive and non-naive CD4

resultsIn isolated naive CD4

conclusionThe results of the study indicate significant immunomodulatory properties of MSCs, as under Th17-polarizing conditions MSCs are still able to control T-cell differentiation and proinflammatory cytokine production in both HD and patients with autoimmune arthritis.

Indexed as

ArthritisAutoimmune DiseasesMesenchymal Stem CellsCytokinesHumansInterleukin-17Interleukin-9CytokinesInterleukin-17Interleukin-9ArthritisMesenchymal stem cellT lymphocytes

Identifiers

PMID37525265
OpenAlexW4385427082

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.