Evidence map›Paper›PMID 37525211›Full record

Trial reportBMC oral health2023

The effect of low-dose aspirin on aspirin triggered lipoxin, interleukin 1 beta, and prostaglandin E2 levels in periapical fluid: a double-blind randomized clinical trial.

Elham Khoshbin, Razieh Salehi, Rooholah Behroozi, Soroush Sadr, Alireza Zamani, Maryam Farhadian, Hamed Karkehabadi

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07450235 (Strategic Inflammation Modulation and Advanced Regenerative Therapy of Dental PULP), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07450235 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Strategic Inflammation Modulation and Advanced Regenerative Therapy of Dental PULP

Typeobservational_patient_registrySponsorUniversité de NantesRan2026 to 2028Enrolled50ConditionsPulpitis, Healthy
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Impacts of Oxylipins on ischemic stroke: from pathophysiology to clinical phenotypes.Metabolomics : Official journal of the Metabolomic Society · 2025
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elham KhoshbinDepartment of Endodontics, Dental School, Hamadan University of Medical Sciences, Hamadan, Iran.
Razieh SalehiDepartment of Endodontics, Dental School, Hamadan University of Medical Sciences, Hamadan, Iran.
Rooholah BehrooziDepartment of Endodontics, Dental School, Hamadan University of Medical Sciences, Hamadan, Iran.
Soroush SadrDepartment of Endodontics, Dental School, Hamadan University of Medical Sciences, Hamadan, Iran.
Alireza ZamaniDepartment of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Maryam FarhadianDepartment of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
Hamed KarkehabadiDepartment of Endodontics, Dental School, Hamadan University of Medical Sciences, Hamadan, Iran. hamed_karkehabadi@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of pro-resolving mediators in inflammation is a new concern in research. The effect of low-dose aspirin on production of a special kind of these mediators named aspirin triggered lipoxin (ATL) has been studied on different tissues. This randomized clinical trial evaluated the effect of low-dose aspirin on ATL and pro-inflammatory mediators' level in periapical fluid of necrotic teeth with large lesions.

methodsTwenty-four patients with necrotic pulp and periapical lesion were randomly assigned to low-dose aspirin and placebo groups. In the first appointment, canals were shaped up to F3 size and #40 K-file and cleaned with 10 milliliters 2.5% sodium hypochlorite and 17% Ethylenediaminetetraacetic acid. Periapical fluid was sampled by a paper cone. The tooth was temporized without any intracanal medication. Tablets were administered for 7 days, then the teeth were re-opened and the sampling were repeated. Interleukin-1 beta (IL-1β), prostaglandin E2 (PGE2) and ATL were analyzed by enzyme-linked immunosorbent assay. Data were analyzed with paired t-test using SPSS statistical software, version 21 (α = 0.05).

resultsA significant reduction in PGE2 and IL-1β was noted in the aspirin-treated group while an increase in ATL was observed (P < 0.001). There was no significant difference in the mediator scores before and after in the placebo-treated group (P > 0.05).

conclusionLow-dose aspirin can influence the inflammatory process by reducing pro-inflammatory mediators such as PGE2 and IL-1β, as well as increasing the pro-resolving mediators such as ATL.

trial registrationIRCT20191211045702N1.

Indexed as

AspirinLipoxinsAnti-Inflammatory Agents, Non-SteroidalDinoprostoneHumansInflammation MediatorsInterleukin-1betaAnti-Inflammatory Agents, Non-SteroidalAspirinDinoprostoneInflammation MediatorsInterleukin-1betaLipoxinsAspirin triggered lipoxinInterleukin 1 betaLow-dose aspirinProstaglandin E2Specialized pro-resolving mediators

Identifiers

PMID37525211
PMCPMC10388445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.