Evidence map›Paper›PMID 37525176›Full record

ArticleBMC public health2023

Mitigation role of physical exercise participation in the relationship between blood cadmium and sleep disturbance: a cross-sectional study.

Yanwei You, Yuquan Chen, Yangchang Zhang, Qi Zhang, Yaohui Yu, Qiang Cao

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In one paragraph

Article in BMC public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  17. Associations of a metal mixture and vitamin D with sleep duration among adolescents and young adults from the 2011-2018 NHANES cycles.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yanwei You *Division of Sports Science & Physical Education, Tsinghua University, Beijing, 100084, China.
Yuquan Chen *Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100020, China.
Yangchang Zhang *Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing, 100169, China.
Qi ZhangUndergraduate Department, Taishan University, Taian, 250111, China.
Yaohui YuSchool of Public Health, North China University of Science and Technology, Tangshan, 063210, Hebei, China.
Qiang CaoDepartment of Earth Sciences, Kunming University of Science and Technology, Kunming, 650093, China. 2918292861@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The neurotoxicity of heavy metals received increasingly attention in recent years. Sleeping is regulated and coordinated by nervous system, however, the health hazard of heavy metal like cadmium (Cd) exposure on sleep health remained unknown. Rescue strategies like physical exercise (PE) has emerged to mitigate such influence. An epidemiological design with cross-sectional data from National Health and Nutrition Examination Survey 2007-2010 was applied. The relationship between three blood heavy metals [cadmium (Cd), lead (Pb), mercury (Hg)] and sleep disturbance was analyzed. A total of 8,751 participants were finally included in and the weighted participants were 330,239,463. Weighted quantile sum (WQS) regression indicated that mixed blood metals were positively related to risk of sleep disturbance and the mixture effect of exposure to heavy metals was mainly attributable to Cd (89.1%). Weighted logistic regression showed a significant positive association between the highest quartile of blood Cd and sleep disturbance [(OR (95% CI)): 1.191 (1.014,1.400), p = 0.036] in the fully adjusted model, while no association was found under Pb and Hg exposure. In the association between Q3 and Q4 level of blood Cd and sleep disturbance, moderate-to-vigorous physical exercise group had lower risks than none and low exercise group. In the restricted cubic spline model, it was also verified that higher PE participation was associated with the lowest incidence of sleep disturbance with the increment in Cd concentration. Our study suggested that both policy makers and the public should minimize heavy metal exposure. Moreover, conducting moderate to vigorous physical exercise is a protecting factor to mitigate Cd's influence on sleep health.

Indexed as

MercuryMetals, HeavySleep Wake DisordersCadmiumCross-Sectional StudiesHumansLeadNutrition SurveysCadmiumLeadMercuryMetals, HeavyCadmiumCross-sectional studyHeavy metalNHANESPhysical exerciseSleep disturbance

Identifiers

PMID37525176
PMCPMC10391747

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.