ArticleBMC geriatrics2023
Prognostic relevance of gait-related cognitive functions for dementia conversion in amnestic mild cognitive impairment.
Article in BMC geriatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Advances in gait research related to Alzheimer's disease.Frontiers in neurology · 2025Pooled it
- Gait speed as a superior screening indicator for mild cognitive impairment compared to walk ratio and dual-task cost: a cross-sectional study.European geriatric medicine · 2025Article
- Effects of external ankle support and dual-tasking on gait in patients with chronic lateral ankle instability.BMC sports science, medicine & rehabilitation · 2025Article
- Association between high plasma p-tau181 level and gait changes in patients with mild cognitive impairment.Scientific reports · 2025Article
- Extracted step parameters during the timed up and go test discriminate between groups with different levels of cognitive ability-a cross-sectional study.BMC geriatrics · 2025Article
- Predictive power of gait and gait-related cognitive measures in amnestic mild cognitive impairment: a machine learning analysis.Frontiers in human neuroscience · 2023Article
- Artificial intelligence detection of cognitive impairment in older adults during walking.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundIncreasing research suggests that gait abnormalities can be a risk factor for Alzheimer's Disease (AD). Notably, there is growing evidence highlighting this risk factor in individuals with amnestic Mild Cognitive Impairment (aMCI), however further studies are needed. The aim of this study is to analyze cognitive tests results and brain-related measures over time in aMCI and examine how the presence of gait abnormalities (neurological or orthopedic) or normal gait affects these trends. Additionally, we sought to assess the significance of gait and gait-related measures as prognostic indicators for the progression from aMCI to AD dementia, comparing those who converted to AD with those who remained with a stable aMCI diagnosis during the follow-up.
methodsFour hundred two individuals with aMCI from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database were included. Robust linear mixed-effects models were used to study the impact of gait abnormalities on a comprehensive neuropsychological battery over 36 months while controlling for relevant medical variables at baseline. The impact of gait on brain measures was also investigated. Lastly, the Cox proportional-hazards model was used to explore the prognostic relevance of abnormal gait and neuropsychological associated tests.
resultsWhile controlling for relevant covariates, we found that gait abnormalities led to a greater decline over time in attention (DSST) and global cognition (MMSE). Intriguingly, psychomotor speed (TMT-A) and divided attention (TMT-B) declined uniquely in the abnormal gait group. Conversely, specific AD global cognition tests (ADAS-13) and auditory-verbal memory (RAVLT immediate recall) declined over time independently of gait profile. All the other cognitive tests were not significantly affected by time or by gait profile. In addition, we found that ventricles size increased faster in the abnormal gait group compared to the normal gait group. In terms of prognosis, abnormal gait (HR = 1.7), MMSE (HR = 1.09), and DSST (HR = 1.03) covariates showed a higher impact on AD dementia conversion.
conclusionsThe importance of the link between gait and related cognitive functions in terms of diagnosis, prognosis, and rehabilitation in aMCI is critical. We showed that in aMCI gait abnormalities lead to executive functions/attention deterioration and conversion to AD dementia.
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