Evidence map›Paper›PMID 37525113›Full record

ReviewBMC infectious diseases2023

A rare case of severe leptospirosis infection presenting as septic shock in a non-endemic area: a case report and literature review.

Junjie Dai, Can Yao, Huaxiang Ling, Binbin Li, Rongchang Chen, Fei Shi

Abstract readReviewCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Review in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Junjie Dai *The Second Clinical Medical College, Jinan University, Shenzhen, 518020, Guangdong, China.
Can Yao *Department of Infectious diseases, The Second Clinical Medical College, The First Affiliated Hospital, Shenzhen People's Hospital, Jinan University, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, China.
Huaxiang Ling *The Second Clinical Medical College, Jinan University, Shenzhen, 518020, Guangdong, China.
Binbin LiDepartment of Infectious diseases, The Second Clinical Medical College, The First Affiliated Hospital, Shenzhen People's Hospital, Jinan University, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, China.
Rongchang ChenKey Laboratory of Shenzhen Respiratory Diseases, Institute of Shenzhen Respiratory Diseases, The Second Clinical Medical College, The First Affiliated Hospital, Shenzhen People's Hospital, Jinan University, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, China. chenrc@vip.163.com.
Fei ShiDepartment of Infectious diseases, The Second Clinical Medical College, The First Affiliated Hospital, Shenzhen People's Hospital, Jinan University, Southern University of Science and Technology), Shenzhen, 518020, Guangdong, China. shi.fei@szhospital.com.

Funding

Enterprises and the Basic and applied Basic Research Foundation of Guangdong Province 2022A1515220169
6 · The paper itself

Abstract

backgroundLeptospirosis is a zoonosis caused by spirochete "genus" leptospira. The clinical presentations of leptospirosis range from an influenza-like presentation of fever and myalgia, to severe forms. Leptospirosis can potentially lead to a misdiagnosis or delay in diagnosis when clinical similarities exist. CASE PRESENTATION: A 63-year-old man presented with fever, shock and thrombocytopenia followed by diffuse pulmonary hemorrhage. Peripheral blood Metagenomic Next-generation Sequencing (mNGS) reported Leptospira interrogans. The patient was treated with piperacillin-tazobactam (TZP) plus doxycycline and improved dramatically after 7 days.

conclusionWe conclude that leptospirosis can potentially lead to a misdiagnosis or delay in diagnosis. Correctly evaluation of thrombocytopenia in acute febrile illnesses facilitates the differential diagnosis of leptospirosis. mNGS can accurately detect Leptospira DNA during the early stage of the infection.

Indexed as

LeptospiraLeptospirosisShock, SepticThrombocytopeniaAnimalsHemorrhageHumansMaleMiddle AgedZoonosesAcute febrile illnessesDifferential diagnosisLeptospirosisThrombocytopenia

Identifiers

PMID37525113
PMCPMC10391985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.