ArticleNature structural & molecular biology2023
Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2.
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Article in Nature structural & molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
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- Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice.bioRxiv : the preprint server for biology · 2026Article
- Aging-related signature stratifies LUAD prognosis and uncovers senescence-induced chemoresistance via NF-κB/RELA activation.Respiratory research · 2025Article
- Molecular insight into interactions between the Taf14, Yng1 and Sas3 subunits of the NuA3 complex.Nature communications · 2024Article
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Authors and funding
17 authors at 7 institutions in 3 countries.
Adam H Tencer *Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.
Yucong Yu *Department of Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA.
Sebastien Z Causse *Institut National de la Santé et de la Recherche Médicale (Inserm), LNC UMR1231, Dijon, France and Université de Bourgogne Franche-Comté, Dijon, France.
Grant R Campbell *Division of Infectious Diseases, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-3927-1994
Brianna J KleinDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID http://orcid.org/0000-0003-2479-8013
Hongwen XuanDepartment of Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA.
Jessy CartierInstitut National de la Santé et de la Recherche Médicale (Inserm), LNC UMR1231, Dijon, France and Université de Bourgogne Franche-Comté, Dijon, France.
Mark A MilesDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia.ORCID http://orcid.org/0000-0002-2162-2939
Nitika GauravDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.
Aymeric ZadoroznyjInstitut National de la Santé et de la Recherche Médicale (Inserm), LNC UMR1231, Dijon, France and Université de Bourgogne Franche-Comté, Dijon, France.
Tina A HoltDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.ORCID http://orcid.org/0000-0003-3027-4478
Hong WenDepartment of Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0001-8739-4572
Christine J HawkinsDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria, Australia.ORCID http://orcid.org/0000-0001-8120-1071
Stephen A SpectorDivision of Infectious Diseases, Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. saspector@health.ucsd.edu.ORCID http://orcid.org/0000-0002-1882-4855
Laurence DubrezInstitut National de la Santé et de la Recherche Médicale (Inserm), LNC UMR1231, Dijon, France and Université de Bourgogne Franche-Comté, Dijon, France. laurence.dubrez@u-bourgogne.fr.ORCID http://orcid.org/0000-0002-7030-2181
Xiaobing ShiDepartment of Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA. xiaobing.shi@vai.org.ORCID http://orcid.org/0000-0001-5242-8189
Tatiana G KutateladzeDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA. tatiana.kutateladze@cuanschutz.edu.ORCID http://orcid.org/0000-0001-7375-6990
Inserm · FRUniversity of Colorado Denver · USVan Andel Institute · USLa Trobe University · AUUC San Diego Health System · USUniversity of Colorado Anschutz Medical Campus · USUniversity of South Dakota · US
Funding
LOC-IMPAACT Leadership GroupPharmacokinetics and Safety of Remdesivir for Treatment of COVID-19 in Pregnant Women in the USUM1AI068632 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI Sharon A Nachman · 2011 to 2026
$278.1MStatistical and Data Management Center-Pediatric,Adolescent, and Maternal CTGUM1AI068616 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Sean Scott Brummel, Marlene Ann Cooper · 2011 to 2026
$155.6MLC - IMPAACT Leadership GroupUM1AI106716 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$47.2MNanopeptide Targeting of HIV-CNS Reservoirs without ReactivationR01NS104015 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SPECTOR, STEPHEN A · 2017 to 2021
$2.9MTargeting acetylated histone H4 by MLL4R01AG067664 · NIA · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2021 to 2025
$2.1MRole of GAS41 in Human CancerR01CA204020 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI SHI, XIAOBING · 2016 to 2020
$2.0MTargeting HIV Myeloid Reservoirs in the CNS by IAP and TREM1 InhibitionR01MH128021 · NIMH · UNIVERSITY OF SOUTH DAKOTA · PI CAMPBELL, GRANT R · 2021 to 2025
$1.9MMolecular analysis of ASH1LR01CA252707 · NCI · UNIVERSITY OF COLORADO DENVER · PI TATIANA G KUTATELADZE · 2020 to 2026
$1.9MThe role of JADE in HBO complexesR01HL151334 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2023
$1.8MDiscovery of small molecules targeting the histone acetylation reader ENLR01CA255506 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI WEN, HONG · 2021 to 2024
$1.7MHigh Throughput Screen for Inhibitors of the YEATS2 Histone Acylation ReaderR01CA268440 · NCI · VAN ANDEL RESEARCH INSTITUTE · PI SHI, XIAOBING · 2022 to 2025
$1.7MEpigenetic mechanisms for regulation of p300R01GM135671 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2020 to 2023
$1.4MNCI NIH HHS R01 CA204020NCI NIH HHS R01 CA252707NCI NIH HHS R01 CA255506NCI NIH HHS R01 CA268440NHLBI NIH HHS R01 HL151334NIAID NIH HHS UM1 AI068616NIAID NIH HHS UM1 AI068632NIAID NIH HHS UM1 AI106716NIA NIH HHS R01 AG067664NIA NIH HHS R56 AG067664NIGMS NIH HHS R01 GM125195NIGMS NIH HHS R01 GM135671NIMH NIH HHS R01 MH128021NINDS NIH HHS R01 NS104015
Abstract
The inhibitor of apoptosis protein BIRC2 regulates fundamental cell death and survival signaling pathways. Here we show that BIRC2 accumulates in the nucleus via binding of its second and third BIR domains, BIRC2
Indexed as
Inhibitor of Apoptosis ProteinsThiazolesApoptosisHumansSignal TransductionUbiquitin-Protein LigasesBIRC2 protein, humanInhibitor of Apoptosis ProteinsLCL161ThiazolesUbiquitin-Protein Ligases
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