ArticleNature nanotechnology2023
Isothermal self-assembly of multicomponent and evolutive DNA nanostructures.
Article in Nature nanotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Advances in DNA nanostructures for pathogenic microorganisms.Materials today. Bio · 2026Review
- DNA Nanotechnology in the Undergraduate Laboratory: Isothermal Assembly and Quantification of DNA Nanostructures.JACS Au · 2026Article
- A thermodynamically favoured molecular computer.Nature · 2026Article
- Light-responsive DNA nanostructures.Nature reviews. Chemistry · 2026Review
- Bioproduction of ∼10 knt single-stranded DNA for constructing large DNA origami structures.Materials today. Bio · 2026Article
- Programmable next-generation supramolecular self-assembled materials as drug delivery systems.Bioactive materials · 2026Review
- Optimising DNA origami assembly by reducing off-target interactions.Nature communications · 2026Article
- Paranemic Cohesion of DNA under Isothermal Conditions.JACS Au · 2026Article
- Giant photorefractive and photoexpansion effects in a van der Waals semiconductor.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Modular Scaffold Crystals for Programmable Installation and Structural Observation of DNA-Binding Proteins.bioRxiv : the preprint server for biology · 2026Article
- Dynamic Decoration of DNA Scaffolds for High-Resolution Cancer Cell Subtyping.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Uncovering Design and Assembly Rules for mRNA-DNA Origami.Nano letters · 2026Article
- Complex cooperativity in DNA origami revealed via design-dependent defectivity.Nucleic acids research · 2026Article
- Ultra-Fast Isothermal Formation of DNA Nanostructures in Culture Media: Application to In Situ Assembly of DNA Origami With Living Cells.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Hybridization chain reaction-based DNA nanoframeworks for biosensing and therapeutic applications.Nature protocols · 2026Review
- Azobenzene DNA Intercalator/Cyclodextrin Pseudo-Rotaxane: From Photoswitchable Chirality and Fluorescence to DNA Melting Control.ChemistryOpen · 2025Article
- Unraveling the Folding Dynamics of DNA Origami Structures.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Quantifying RNA Degradation with Single-Molecule Nanopore Sensing.Analytical chemistry · 2025Article
- DNA Condensation-Inspired Assembly of DNA Nanotubes into Reversible Superstructures: A Base Pairing-Orthogonal Way to Create Rings, Bundles, or Vast Networks.Journal of the American Chemical Society · 2025Article
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Abstract
Thermal annealing is usually needed to direct the assembly of multiple complementary DNA strands into desired entities. We show that, with a magnesium-free buffer containing NaCl, complex cocktails of DNA strands and proteins can self-assemble isothermally, at room or physiological temperature, into user-defined nanostructures, such as DNA origamis, single-stranded tile assemblies and nanogrids. In situ, time-resolved observation reveals that this self-assembly is thermodynamically controlled, proceeds through multiple folding pathways and leads to highly reconfigurable nanostructures. It allows a given system to self-select its most stable shape in a large pool of competitive DNA strands. Strikingly, upon the appearance of a new energy minimum, DNA origamis isothermally shift from one initially stable shape to a radically different one, by massive exchange of their constitutive staple strands. This method expands the repertoire of shapes and functions attainable by isothermal self-assembly and creates a basis for adaptive nanomachines and nanostructure discovery by evolution.
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