ArticleNature metabolism2023
An electrogenetic interface to program mammalian gene expression by direct current.
Article in Nature metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Nanomedicine beyond carriers - devices, cells & living therapeutics.Biomedical microdevices · 2026Review
- Biointegrated Battery-Based Electroceuticals.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Piezo-Bio Interaction Interfaces: The Linchpin of Piezoelectric Nanomaterials Toward Biomedicine.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Next-generation programmable cell therapies for precision medicine.Nature reviews. Genetics · 2026Review
- AI-orchestrated design-build-test-learn is the future of mammalian biodesign.Nature biomedical engineering · 2026Article
- Bioelectronic synthesis of hydrogen sulfide enables spatiotemporal regulation of protein modification and cellular redox.Science advances · 2026Article
- Traceless Regulation of Genetic Circuitry.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- On-demand cancer immunotherapy via single-cell encapsulation of synthetic circuit-engineered cells.Science advances · 2026Article
- Remote-controlled genetics: A new frontier in precision therapy.Clinical and translational medicine · 2025Article
- Regulation of therapeutic protein release in response to circadian biomarkers.Nature communications · 2025Article
- Implantable Light-Powered Human Designer Cells for Electrical Energy Generation.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Bioelectrosynthesis of Signaling Molecules for Selective Modulation of Cell Signaling.Angewandte Chemie (International ed. in English) · 2025Article
- Electrochemistry as a Tool for Redox-Based Bio-Information Processing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Electromagnetic wireless remote control of mammalian transgene expression.Nature nanotechnology · 2025Article
- Advances in Medical Devices for Augmented Acupuncture Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Genetics-Based Targeting Strategies for Precise Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Nitroglycerin-responsive gene switch for the on-demand production of therapeutic proteins.Nature biomedical engineering · 2025Article
- Implantable bioelectronic devices for photoelectrochemical and electrochemical modulation of cells and tissues.Nature reviews bioengineering · 2025Article
- Designer mammalian living materials through genetic engineering.Bioactive materials · 2025Review
- Materials and device strategies to enhance spatiotemporal resolution in bioelectronics.Nature reviews. Materials · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wearable electronic devices are playing a rapidly expanding role in the acquisition of individuals' health data for personalized medical interventions; however, wearables cannot yet directly program gene-based therapies because of the lack of a direct electrogenetic interface. Here we provide the missing link by developing an electrogenetic interface that we call direct current (DC)-actuated regulation technology (DART), which enables electrode-mediated, time- and voltage-dependent transgene expression in human cells using DC from batteries. DART utilizes a DC supply to generate non-toxic levels of reactive oxygen species that act via a biosensor to reversibly fine-tune synthetic promoters. In a proof-of-concept study in a type 1 diabetic male mouse model, a once-daily transdermal stimulation of subcutaneously implanted microencapsulated engineered human cells by energized acupuncture needles (4.5 V DC for 10 s) stimulated insulin release and restored normoglycemia. We believe this technology will enable wearable electronic devices to directly program metabolic interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.