Evidence map›Paper›PMID 37524532›Full record

ArticleNeurology2023

Serial Nigrostriatal Dopaminergic Imaging in Mild Cognitive Impairment With Lewy Bodies, Alzheimer Disease, and Age-Matched Controls.

Rory Durcan, Gemma Roberts, Calum A Hamilton, Paul C Donaghy, Kim Howe, Sean J Colloby, Louise M Allan, Michael Firbank, Sarah Lawley, George S Petrides and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Cutaneous Phosphorylated Alpha-Synuclein in Lewy Body Dementia.Annals of clinical and translational neurology · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Lewy body dementia: Overcoming barriers and identifying solutions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  8. Review
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 1 institution in 2 countries.

Rory DurcanFrom the Translational and Clinical Research Institute (R.D., G.R., C.A.H., P.C.D., S.J.C., M.F., S.L., J.-P.T., A.J.T.), Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality; Nuclear Medicine Department (G.R., K.H., G.S.P., J.J.L.), Royal Victoria Infirmary, Newcastle Upon Tyne; University of Exeter Medical School (L.M.A.), St Luke's Campus, University of Exeter; and Department of Psychiatry (J.T.O.B.), University of Cambridge School of Clinical Medicine, United Kingdom.
Gemma RobertsFrom the Translational and Clinical Research Institute (R.D., G.R., C.A.H., P.C.D., S.J.C., M.F., S.L., J.-P.T., A.J.T.), Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality; Nuclear Medicine Department (G.R., K.H., G.S.P., J.J.L.), Royal Victoria Infirmary, Newcastle Upon Tyne; University of Exeter Medical School (L.M.A.), St Luke's Campus, University of Exeter; and Department of Psychiatry (J.T.O.B.), University of Cambridge School of Clinical Medicine, United Kingdom. gemma.roberts@newcastle.ac.uk.ORCID 0000-0002-6445-4023
Calum A HamiltonFrom the Translational and Clinical Research Institute (R.D., G.R., C.A.H., P.C.D., S.J.C., M.F., S.L., J.-P.T., A.J.T.), Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality; Nuclear Medicine Department (G.R., K.H., G.S.P., J.J.L.), Royal Victoria Infirmary, Newcastle Upon Tyne; University of Exeter Medical School (L.M.A.), St Luke's Campus, University of Exeter; and Department of Psychiatry (J.T.O.B.), University of Cambridge School of Clinical Medicine, United Kingdom.ORCID 0000-0002-9812-3150
Paul C DonaghyFrom the Translational and Clinical Research Institute (R.D., G.R., C.A.H., P.C.D., S.J.C., M.F., S.L., J.-P.T., A.J.T.), Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality; Nuclear Medicine Department (G.R., K.H., G.S.P., J.J.L.), Royal Victoria Infirmary, Newcastle Upon Tyne; University of Exeter Medical School (L.M.A.), St Luke's Campus, University of Exeter; and Department of Psychiatry (J.T.O.B.), University of Cambridge School of Clinical Medicine, United Kingdom.
Kim HoweFrom the Translational and Clinical Research Institute (R.D., G.R., C.A.H., P.C.D., S.J.C., M.F., S.L., J.-P.T., A.J.T.), Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality; Nuclear Medicine Department (G.R., K.H., G.S.P., J.J.L.), Royal Victoria Infirmary, Newcastle Upon Tyne; University of Exeter Medical School (L.M.A.), St Luke's Campus, University of Exeter; and Department of Psychiatry (J.T.O.B.), University of Cambridge School of Clinical Medicine, United Kingdom.
Sean J CollobyFrom the Translational and Clinical Research Institute (R.D., G.R., C.A.H., P.C.D., S.J.C., M.F., S.L., J.-P.T., A.J.T.), Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality; Nuclear Medicine Department (G.R., K.H., G.S.P., J.J.L.), Royal Victoria Infirmary, Newcastle Upon Tyne; University of Exeter Medical School (L.M.A.), St Luke's Campus, University of Exeter; and Department of Psychiatry (J.T.O.B.), University of Cambridge School of Clinical Medicine, United Kingdom.
Louise M AllanFrom the Translational and Clinical Research Institute (R.D., G.R., C.A.H., P.C.D., S.J.C., M.F., S.L., J.-P.T., A.J.T.), Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality; Nuclear Medicine Department (G.R., K.H., G.S.P., J.J.L.), Royal Victoria Infirmary, Newcastle Upon Tyne; University of Exeter Medical School (L.M.A.), St Luke's Campus, University of Exeter; and Department of Psychiatry (J.T.O.B.), University of Cambridge School of Clinical Medicine, United Kingdom.ORCID 0000-0002-8912-4901
Michael FirbankFrom the Translational and Clinical Research Institute (R.D., G.R., C.A.H., P.C.D., S.J.C., M.F., S.L., J.-P.T., A.J.T.), Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality; Nuclear Medicine Department (G.R., K.H., G.S.P., J.J.L.), Royal Victoria Infirmary, Newcastle Upon Tyne; University of Exeter Medical School (L.M.A.), St Luke's Campus, University of Exeter; and Department of Psychiatry (J.T.O.B.), University of Cambridge School of Clinical Medicine, United Kingdom.
Sarah LawleyFrom the Translational and Clinical Research Institute (R.D., G.R., C.A.H., P.C.D., S.J.C., M.F., S.L., J.-P.T., A.J.T.), Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality; Nuclear Medicine Department (G.R., K.H., G.S.P., J.J.L.), Royal Victoria Infirmary, Newcastle Upon Tyne; University of Exeter Medical School (L.M.A.), St Luke's Campus, University of Exeter; and Department of Psychiatry (J.T.O.B.), University of Cambridge School of Clinical Medicine, United Kingdom.
George S PetridesFrom the Translational and Clinical Research Institute (R.D., G.R., C.A.H., P.C.D., S.J.C., M.F., S.L., J.-P.T., A.J.T.), Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality; Nuclear Medicine Department (G.R., K.H., G.S.P., J.J.L.), Royal Victoria Infirmary, Newcastle Upon Tyne; University of Exeter Medical School (L.M.A.), St Luke's Campus, University of Exeter; and Department of Psychiatry (J.T.O.B.), University of Cambridge School of Clinical Medicine, United Kingdom.
Jim J LloydFrom the Translational and Clinical Research Institute (R.D., G.R., C.A.H., P.C.D., S.J.C., M.F., S.L., J.-P.T., A.J.T.), Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality; Nuclear Medicine Department (G.R., K.H., G.S.P., J.J.L.), Royal Victoria Infirmary, Newcastle Upon Tyne; University of Exeter Medical School (L.M.A.), St Luke's Campus, University of Exeter; and Department of Psychiatry (J.T.O.B.), University of Cambridge School of Clinical Medicine, United Kingdom.
John-Paul TaylorFrom the Translational and Clinical Research Institute (R.D., G.R., C.A.H., P.C.D., S.J.C., M.F., S.L., J.-P.T., A.J.T.), Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality; Nuclear Medicine Department (G.R., K.H., G.S.P., J.J.L.), Royal Victoria Infirmary, Newcastle Upon Tyne; University of Exeter Medical School (L.M.A.), St Luke's Campus, University of Exeter; and Department of Psychiatry (J.T.O.B.), University of Cambridge School of Clinical Medicine, United Kingdom.
John T O'BrienFrom the Translational and Clinical Research Institute (R.D., G.R., C.A.H., P.C.D., S.J.C., M.F., S.L., J.-P.T., A.J.T.), Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality; Nuclear Medicine Department (G.R., K.H., G.S.P., J.J.L.), Royal Victoria Infirmary, Newcastle Upon Tyne; University of Exeter Medical School (L.M.A.), St Luke's Campus, University of Exeter; and Department of Psychiatry (J.T.O.B.), University of Cambridge School of Clinical Medicine, United Kingdom.
Alan J ThomasFrom the Translational and Clinical Research Institute (R.D., G.R., C.A.H., P.C.D., S.J.C., M.F., S.L., J.-P.T., A.J.T.), Newcastle University, Biomedical Research Building, Campus for Ageing and Vitality; Nuclear Medicine Department (G.R., K.H., G.S.P., J.J.L.), Royal Victoria Infirmary, Newcastle Upon Tyne; University of Exeter Medical School (L.M.A.), St Luke's Campus, University of Exeter; and Department of Psychiatry (J.T.O.B.), University of Cambridge School of Clinical Medicine, United Kingdom.
University of Exeter · GB

Funding

Department of HealthMedical Research Council MR/W000229/1
6 · The paper itself

Abstract

BACKGROUND AND

objectivesProgressive nigrostriatal pathway degeneration occurs in individuals with dementia with Lewy bodies (LB). Our objective was to investigate whether repeat 123[I]-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (FP-CIT) single photon emission computed tomography (SPECT) can identify progressive dopaminergic loss in mild cognitive impairment (MCI) with Lewy bodies (MCI-LB).

methodsIndividuals with MCI-LB and MCI due to Alzheimer disease (MCI-AD) underwent comprehensive clinical assessment, 123[I]-FP-CIT SPECT at baseline and annual reviews, and baseline cardiac

resultsWe recruited 20 individuals with MCI-AD, 11 with possible MCI-LB, 25 with probable MCI-LB, and 29 age-matched controls. The mean time between baseline and the final image was 1.6 years (SD = 0.9, range 1.0-4.3). The annual estimated change in SBR was 0.23 for controls (95% CI -0.07 to 0.53), -0.09 (-0.55 to 0.36) for MCI-AD, -0.50 (-1.03 to 0.04) for possible MCI-LB, and -0.48 (-0.89 to -0.06) for probable MCI-LB. The median annual percentage change in SBR in MCI-LB was -5.6% (95% CI -8.2% to -2.9%) and 2.1% (-3.5% to 8.0%) for MCI-AD. The extrapolated time for a normal scan to become abnormal was 6 years. Controls and MCI-AD showed no significant change in dopaminergic binding over time. The mean test-retest variation in controls was 12% (SD 5.5%), which cautions against overinterpretation of small changes on repeat scanning. DISCUSSION: Progressive dopaminergic loss in the striatum is detectable using 123[I]-FP-CIT SPECT in MCI-LB at a group level. In clinical practice, individual change in striatal 123[I]-FP-CIT uptake seems to be of limited diagnostic value because of high test-retest variation. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that longitudinal declines in striatal uptake measured using 123[I]-FP-CIT SPECT are associated with MCI due to Lewy body disease but not MCI due to Alzheimer disease.

Indexed as

Alzheimer DiseaseCognitive DysfunctionLewy Body DiseaseAgedDopaminergic ImagingHumansTomography, Emission-Computed, Single-PhotonTropanes2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropaneTropanes

Identifiers

PMID37524532
PMCPMC10516282
OpenAlexW4385410561

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.