Evidence map›Paper›PMID 37524225›Full record

ArticleCancer letters2023

Inducible nitric oxide synthase (iNOS)-activated Cxcr2 signaling in myeloid cells promotes TGFβ-dependent squamous cell carcinoma lung metastasis.

Xing Li, Yao Ke, Ariel L Hernandez, Jingjing Yu, Li Bian, Spencer C Hall, Kyle Nolan, Jing H Wang, Christian D Young, Xiao-Jing Wang

Open access · greenAbstract read
In one paragraph

Article in Cancer letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Xing LiHospital of Stomatology, Jilin University, Changchun, 130021, PR China; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Yao KeDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Ariel L HernandezDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Jingjing YuDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Li BianDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Spencer C HallDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Kyle NolanDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Jing H WangDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA; UPMC Hillman Cancer Center, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
Christian D YoungDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. Electronic address: christian.young@cuanschutz.edu.
Xiao-Jing WangDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA; Department of Pathology & Laboratory Medicine, University of California Davis, Sacramento, CA, 95817, USA. Electronic address: drxwang@ucdavis.edu.
University of Colorado Anschutz Medical Campus · USJilin University · CNUniversity of California Davis Medical Center · USUPMC Hillman Cancer Center · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
WILD TYPE P53-BASED ADJUVANT IMMUNOTHERAPY FOR SCCHNP50CA097190 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Greg M. Delgoffe · 2004 to 2026
$49.6M
Treating recurrent HNSCC with radiation and dual TGF-Beta/PD-L1.P50CA261605 · NCI · UNIVERSITY OF COLORADO DENVER · PI JIMENO, ANTONIO, WANG, XIAO-JING · 2021 to 2025
$10.1M
Identifying cellular and molecular signatures from distinct T cell receptor clonotypes associated with favorable immune checkpoint inhibitor responses in HNSCCsR01DE031947 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Robert L. Ferris, Lazar Vujanovic · 2022 to 2026
$3.6M
Elucidating Mechanism of Immune Evasion in Head and Neck CancersR01DE027329 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, JING HONG, WANG, XIAO-JING · 2018 to 2022
$2.8M
Mechanisms of Dual Inhibition of TGFbeta/PD-L1 in HNSCCR01DE028420 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI WANG, JING HONG, WANG, XIAO-JING · 2019 to 2023
$2.7M
Mechanistic connection between HPV-specific TCRs and therapeutic responses to ICI in HPV+ HNSCCR01CA282074 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert L. Ferris, Jing Hong Wang · 2024 to 2026
$2.0M
BLRD VA I01 BX003232NCI NIH HHS P30 CA046934NCI NIH HHS P50 CA097190NCI NIH HHS P50 CA261605NCI NIH HHS R01 CA282074NIDCR NIH HHS R01 DE027329NIDCR NIH HHS R01 DE028420NIDCR NIH HHS R01 DE031947
6 · The paper itself

Abstract

Transforming growth factor beta (TGFβ) activity is linked to metastasis in many cancer types, but whether TGFβ activity is necessary for squamous cell carcinoma (SCC) lung metastasis has not been studied. Here we used a lung metastatic SCC model derived from keratin 15 (K15). Kras

Indexed as

Carcinoma, Non-Small-Cell LungCarcinoma, Squamous CellLung NeoplasmsAnimalsHumansMiceMyeloid CellsNitric OxideNitric Oxide Synthase Type IITransforming Growth Factor betaNitric OxideNitric Oxide Synthase Type IITransforming Growth Factor betaL-NILMyeloid-derived suppressor cellsOral cancerSmad4 deletionSpontaneous lung metastasis model

Identifiers

PMID37524225
PMCPMC10530117
OpenAlexW4385383436

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.