Evidence map›Paper›PMID 37523785›Full record

ArticleACS biomaterials science & engineering2023

Bioreducible Gene Delivery Platform that Promotes Intracellular Payload Release and Widespread Brain Dispersion.

Divya Rao, Gijung Kwak, Heng Wang, Charles G Eberhart, Justin Hanes, Jung Soo Suk

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Divya RaoCenter for Nanomedicine at Wilmer Eye Institute, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, United States.
Gijung KwakCenter for Nanomedicine at Wilmer Eye Institute, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, United States.ORCID 0000-0001-6908-9638
Heng WangDepartment of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.
Charles G EberhartDepartment of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, United States.
Justin HanesCenter for Nanomedicine at Wilmer Eye Institute, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, United States.
Jung Soo SukCenter for Nanomedicine at Wilmer Eye Institute, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, United States.ORCID 0000-0002-2437-0001
Johns Hopkins University · US

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Ji Yi · 1985 to 2026
$22.1M
Innovative systemic gene therapy for treating Parkinson's diseaseR01NS111102 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI PRICE, RICHARD J., SUK, JUNG SOO · 2019 to 2023
$2.6M
Nanocage-based systemic delivery of TGFβ trap for immunomodulation of brain neoplasmsR01NS119609 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI LIM, MICHAEL, SUK, JUNG SOO · 2021 to 2025
$2.4M
NEI NIH HHS P30 EY001765NINDS NIH HHS R01 NS111102NINDS NIH HHS R01 NS119609
6 · The paper itself

Abstract

We here introduce a novel bioreducible polymer-based gene delivery platform enabling widespread transgene expression in multiple brain regions with therapeutic relevance following intracranial convection-enhanced delivery. Our bioreducible nanoparticles provide markedly enhanced gene delivery efficacy

Indexed as

Gene Transfer TechniquesPolymersBrainGenetic TherapyPolymersbioreducible polymerbrain extracellular matrixbrain gene therapyintracranial administrationpolymeric nanoparticle.

Identifiers

PMID37523785
PMCPMC11804944
OpenAlexW4385408831

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.