Evidence map›Paper›PMID 37523551›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Activin E-ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice.

Rene C Adam, Dwaine S Pryce, Joseph S Lee, Yuanqi Zhao, Ivory J Mintah, Soo Min, Gabor Halasz, Jason Mastaitis, Gurinder S Atwal, Senem Aykul and 7 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. DietaryGenes · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Activin Actions in Adipocytes.The Journal of clinical endocrinology and metabolism · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Rene C AdamRegeneron Pharmaceuticals, Tarrytown, NY 10591.
Dwaine S PryceRegeneron Pharmaceuticals, Tarrytown, NY 10591.
Joseph S LeeRegeneron Pharmaceuticals, Tarrytown, NY 10591.
Yuanqi ZhaoRegeneron Pharmaceuticals, Tarrytown, NY 10591.
Ivory J MintahRegeneron Pharmaceuticals, Tarrytown, NY 10591.
Soo MinRegeneron Pharmaceuticals, Tarrytown, NY 10591.
Gabor HalaszRegeneron Pharmaceuticals, Tarrytown, NY 10591.ORCID 0000-0002-3332-033X
Jason MastaitisRegeneron Pharmaceuticals, Tarrytown, NY 10591.
Gurinder S AtwalRegeneron Pharmaceuticals, Tarrytown, NY 10591.
Senem AykulRegeneron Pharmaceuticals, Tarrytown, NY 10591.
Vincent IdoneRegeneron Pharmaceuticals, Tarrytown, NY 10591.
Aris N EconomidesRegeneron Pharmaceuticals, Tarrytown, NY 10591.ORCID 0000-0002-6508-8942
Luca A LottaRegeneron Pharmaceuticals, Tarrytown, NY 10591.
Andrew J MurphyRegeneron Pharmaceuticals, Tarrytown, NY 10591.
George D YancopoulosRegeneron Pharmaceuticals, Tarrytown, NY 10591.
Mark W SleemanRegeneron Pharmaceuticals, Tarrytown, NY 10591.ORCID 0000-0002-3329-0919
Viktoria GusarovaRegeneron Pharmaceuticals, Tarrytown, NY 10591.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Body fat distribution is a heritable risk factor for cardiovascular and metabolic disease. In humans, rare Inhibin beta E (

Indexed as

Diabetes Mellitus, Type 2LipolysisActivin Receptors, Type IActivinsAdipose TissueAdiposityAnimalsHumansMiceObesityPPAR gammaActivin Receptors, Type IActivinsACVR1C protein, humanPPAR gammaACVR1Cbody fat distributiondiabetesINHBE (activin E)lipolysis

Identifiers

PMID37523551
PMCPMC10410708

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.