Evidence map›Paper›PMID 37523539›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Using single-cell RNA sequencing to generate predictive cell-type-specific split-GAL4 reagents throughout development.

Yu-Chieh David Chen, Yen-Chung Chen, Raghuvanshi Rajesh, Nathalie Shoji, Maisha Jacy, Haluk Lacin, Ted Erclik, Claude Desplan

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 40 citations in OpenAlex.

  1. Regulatory logic of neuronal differentiation in theProceedings of the National Academy of Sciences of the United States of America · 2026
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  6. High-resolution single-cell analyses reveal evolutionary constraints and evolvability of sexual circuits inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Regulatory logic of neuronal identity specification inbioRxiv : the preprint server for biology · 2025
    Article
  8. Article
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  11. High-resolution comparative single-cell transcriptomics ofbioRxiv : the preprint server for biology · 2025
    Article
  12. Searching for partners.Science (New York, N.Y.) · 2025
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  19. Lung Immune Cell Niches and the Discovery of New Cell Subtypes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Yu-Chieh David ChenDepartment of Biology, New York University, New York, NY 10003.
Yen-Chung ChenDepartment of Biology, New York University, New York, NY 10003.
Raghuvanshi RajeshDepartment of Biology, New York University, New York, NY 10003.
Nathalie ShojiDepartment of Biology, New York University, New York, NY 10003.
Maisha JacyDepartment of Biology, New York University, New York, NY 10003.
Haluk LacinDivision of Biological and Biomedical Systems, University of Missouri - Kansas City, Kansas City, MO 64110.
Ted ErclikDepartment of Biology and Cell, University of Toronto - Mississauga, Mississauga, ON L5L 1C6, Canada.
Claude DesplanDepartment of Biology, New York University, New York, NY 10003.ORCID 0000-0002-6914-1413
New York University · USNew York University Abu Dhabi · AEUniversity of Missouri–Kansas City · USUniversity of Toronto · CA

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Cale Whitworth · 2014 to 2026
$13.5M
Signaling from photoreceptors to the optic lobesR01EY013012 · NEI · NEW YORK UNIVERSITY · PI DESPLAN, CLAUDE · 1999 to 2024
$9.4M
Stochastic choices in the retina and optic lobesR01EY013010 · NEI · NEW YORK UNIVERSITY · PI DESPLAN, CLAUDE · 1999 to 2025
$9.1M
Developmental and Genetic Basis of Neural Circuit Formation and BehaviorR01NS122903 · NINDS · WASHINGTON UNIVERSITY · PI Haluk Lacin · 2022 to 2026
$1.9M
Coordination and propagation of cell fate choice in neural circuit assemblyF32EY032750 · NEI · NEW YORK UNIVERSITY · PI CHEN, YU-CHIEH · 2021 to 2023
$213k
NEI NIH HHS F32 EY032750NEI NIH HHS R01 EY013010NEI NIH HHS R01 EY013012NIH HHS P40 OD018537NINDS NIH HHS R01 NS122903
6 · The paper itself

Abstract

Cell-type-specific tools facilitate the identification and functional characterization of the distinct cell types that form the complexity of neuronal circuits. A large collection of existing genetic tools in

Indexed as

Drosophila ProteinsTranscription FactorsAnimalsDrosophilaDrosophila melanogasterGenetic TechniquesSequence Analysis, RNADrosophila ProteinsGAL4 protein, DrosophilaTranscription FactorsDrosophila visual systemMiMIC/CRIMICSingle-cell RNA sequencingSplit-GAL4

Identifiers

PMID37523539
PMCPMC10410749
OpenAlexW4385409641

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.