Evidence map›Paper›PMID 37523502›Full record

SynthesisAmerican journal of respiratory cell and molecular biology2023

Meta-Analysis of COVID-19 BAL Single-Cell RNA Sequencing Reveals Alveolar Epithelial Transitions and Unique Alveolar Epithelial Cell Fates.

Peer W F Karmaus, Aleksandra Tata, Julie M Meacham, Frank Day, David Thrower, Purushothama Rao Tata, Michael B Fessler

Open access · hybridAbstract readMeta-Analysis
In one paragraph

Synthesis in American journal of respiratory cell and molecular biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Reanalysis of Single-Cell RNA-Sequencing Data in Patients with COVID-19: Insights and Limitations.American journal of respiratory cell and molecular biology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Peer W F KarmausImmunity, Inflammation, and Disease Laboratory and.
Aleksandra TataDepartment of Cell Biology, School of Medicine, Duke University, Durham, North Carolina.
Julie M MeachamImmunity, Inflammation, and Disease Laboratory and.
Frank DayOffice of Scientific Computing, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; and.
David ThrowerOffice of Scientific Computing, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina; and.
Purushothama Rao TataDepartment of Cell Biology, School of Medicine, Duke University, Durham, North Carolina.ORCID 0000-0003-4837-0337
Michael B FesslerImmunity, Inflammation, and Disease Laboratory and.ORCID 0000-0002-8262-8613
Immunité et Cancer · FRDuke University · USNational Institute of Environmental Health Sciences · US

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI JOHN N. NORTON · 1985 to 2026
$174.8M
Cooperative Human Tissue Network Support through Duke's BioRepository & Precision Pathology CenterUM1CA239755 · NCI · DUKE UNIVERSITY · PI Shannon Jones McCall · 2019 to 2026
$5.4M
Molecular control of a novel transitional cell state in alveolar regenerationR01HL153375 · NHLBI · DUKE UNIVERSITY · PI Purushothama Rao Tata · 2020 to 2026
$3.4M
Cell Signaling of Host DefenseZ01ES102005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI FESSLER, MICHAEL B · 2006 to 2008
$3.3M
Intramural NIH HHS Z01 ES102005NCI NIH HHS P30 CA014236NCI NIH HHS UM1 CA239755NHLBI NIH HHS R01 HL153375NIEHS NIH HHS Z01 ES102005
6 · The paper itself

Abstract

Single-cell RNA sequencing (scRNA-seq) of BAL cells has provided insights into coronavirus disease (COVID-19). However, reports have been limited by small patient cohorts. We performed a meta-analysis of BAL scRNA-seq data from healthy control subjects (

Indexed as

Alveolar Epithelial CellsCOVID-19Epithelial CellsHumansLungSequence Analysis, RNAalveolar epithelial cellsmeta-analysissevere acute respiratory syndrome coronavirus 2single-cell RNA sequencing

Identifiers

PMID37523502
PMCPMC10704119
OpenAlexW4385410153

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.