Evidence map›Paper›PMID 37523406›Full record

ReviewPLoS neglected tropical diseases2023

Candida haemulonii complex, an emerging threat from tropical regions?

Ugo Françoise, Marie Desnos-Ollivier, Yohann Le Govic, Karine Sitbon, Ruddy Valentino, Sandrine Peugny, Taieb Chouaki, Edith Mazars, André Paugam, Muriel Nicolas and 3 more

Open access · goldAbstract readReview
In one paragraph

Review in PLoS neglected tropical diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. An update on clinically relevant, rare, and emergingClinical microbiology reviews · 2025
    Review
  4. Article
  5. Article
  6. Changing Climate, ChangingJournal of fungi (Basel, Switzerland) · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Deciphering cargo contents in extracellular vesicles ofComputational and structural biotechnology journal · 2025
    Article
  13. Trend ofCurrent medical mycology · 2025
    Article
  14. Candidemia caused by Candida haemulonii: a case report and literature review in neonates.Revista do Instituto de Medicina Tropical de Sao Paulo · 2025
    Review
  15. Antifungal and anti-biofilm effects of hydrazone derivatives onJournal of enzyme inhibition and medicinal chemistry · 2024
    Article
  16. Biological and genomic analyses ofNew microbes and new infections · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Spectrum and management of rareTherapeutic advances in infectious disease
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 4 countries.

Ugo FrançoiseLaboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Martinique, Fort-de-France, Martinique, France.ORCID 0000-0002-3239-5145
Marie Desnos-OllivierCentre National de Référence des Mycoses invasives et Antifongiques, Département de Mycologie, Institut Pasteur, Université de Paris Cité, Paris, France.
Yohann Le GovicLaboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Martinique, Fort-de-France, Martinique, France.
Karine SitbonCentre National de Référence des Mycoses invasives et Antifongiques, Département de Mycologie, Institut Pasteur, Université de Paris Cité, Paris, France.
Ruddy ValentinoService de réanimation, Centre Hospitalier Universitaire de Martinique, Fort-de-France, Martinique, France.
Sandrine PeugnyUnité de Maladies Infectieuses et Tropicales, Centre Hospitalier de Cayenne, Cayenne, Guyane Française, France.
Taieb ChouakiLaboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire Amiens-Picardie, Amiens, France.
Edith MazarsLaboratoire de Parasitologie-Mycologie, Centre Hospitalier de Valenciennes, Valenciennes, France.
André PaugamLaboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France.
Muriel NicolasLaboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Guadeloupe, Pointe-à-Pitre, Guadeloupe, France.
Nicole Desbois-NogardLaboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Martinique, Fort-de-France, Martinique, France.
Olivier LortholaryCentre National de Référence des Mycoses invasives et Antifongiques, Département de Mycologie, Institut Pasteur, Université de Paris Cité, Paris, France.ORCID 0000-0002-8325-8060
French Mycoses Study Group
Centre Hospitalier Universitaire de Martinique · MQInstitut Pasteur · FRCentre Hospitalier Andrée Rosemon · GFCentre Hospitalier de Valenciennes · FRCentre Hospitalier Universitaire Amiens-Picardie · FRCentre Hospitalier Universitaire Pointe-à-Pitre · GPHôpital Cochin · FRHôpital Necker-Enfants Malades · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCandida haemulonii complex-related species are pathogenic yeasts closely related to Candida auris with intrinsic antifungal resistance, but few epidemiological data are available. METHODOLOGY/PRINCIPAL

findingsWe analyzed clinical and demographic characteristics of patients with fungemia due to C. haemulonii complex and related species (C. pseudohaemulonii, C. vulturna) reported in France during 2002-2021, and compared them to data of C. parapsilosis fungemia, as they all can be commensal of the skin. We also conducted a study on adult inpatients and outpatients colonized by C. haemulonii complex, managed at the University Hospital of Martinique during 2014-2020. Finally, we performed a literature review of fungemia due to C. haemulonii complex and related species reported in Medline (1962-2022). In total, we identified 28 fungemia due to C. haemulonii complex in France. These episodes were frequently associated with bacterial infection (38%) and high mortality rate (44%), and differed from C. parapsilosis fungemia by their tropical origin, mainly from Caribbean and Latin America. All isolates showed decreased in vitro susceptibility to amphotericin B and fluconazole. In Martinique, we found that skin colonization was frequent in the community population, while colonization was strongly associated with the presence of foreign devices in ICU patients. The literature review identified 274 fungemia episodes, of which 56 were individually described. As in our national series, published cases originated mainly from tropical regions and exhibited high crude mortality. CONCLUSIONS/SIGNIFICANCE: Multidrug-resistant C. haemulonii complex-related species are responsible for fungemia and colonization in community and hospital settings, especially in tropical regions, warranting closer epidemiological surveillance to prevent a potential C. auris-like threat.

Indexed as

CandidiasisFungemiaAdultAntifungal AgentsCandidaHospitals, UniversityHumansMicrobial Sensitivity TestsSaccharomycetalesAntifungal Agents

Identifiers

PMID37523406
PMCPMC10437918
OpenAlexW4385412017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.