Evidence map›Paper›PMID 37523149›Full record

ArticleAdvanced healthcare materials2023

Near-Infrared Bodipy-Based Molecular Rotors for β-Amyloid Imaging In Vivo.

Lijun Ma, Yujie Geng, Guoyang Zhang, Ziwei Hu, Tony D James, Xuefei Wang, Zhuo Wang

Open access · hybridAbstract read
In one paragraph

Article in Advanced healthcare materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Lijun MaState Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Yujie GengState Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Guoyang ZhangState Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Ziwei HuState Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Tony D JamesDepartment of Chemistry, University of Bath, Bath, BA2 7AY, UK.ORCID 0000-0002-4095-2191
Xuefei WangSchool of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049, China.ORCID 0000-0003-3268-3152
Zhuo WangState Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.ORCID 0000-0002-2858-7646
Beijing University of Chemical Technology · CNUniversity of Bath · GBUniversity of Chinese Academy of Sciences · CN

Funding

Academy of Medical Sciences Newton Advanced Fellowship NAFR13∖1015Beijing Natural Science Foundation 7232342;8222074China Scholarship CouncilNational Key Research and Development Program of China 2021YFC2101500Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University 2020ZD01
6 · The paper itself

Abstract

β-amyloid (Aβ) is one of the important biomarkers for diagnosing Alzheimer's disease (AD). Many near-infrared probes based on the donor-π-acceptor structure have been developed to detect Aβ. Most reported Aβ probes are based on the N,N-dimethylamino group as the ideal donor, which is a widely accepted binding unit. As such, the development of fluorescent probes with improved binding units to detect Aβ is urgently required. Therefore, with this research three anchoring molecular rotor electron donors consisting of cyclic amines of different ring sizes are developed, namely five-membered ring (TPyr), six-membered ring (TPip), and seven-membered ring (THAI). These new anchored molecular rotors are connected to a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) and named TPyrBDP, TPipBDP, and THAIBDP. These probes exhibit high affinities (from 28 to 54 nm) for Aβ

Indexed as

Amyloid beta-PeptidesBoron CompoundsFluorescent DyesAlzheimer DiseaseAnimalsBrainHumansMiceMice, TransgenicPeptide Fragments4,4-difluoro-4-bora-3a,4a-diaza-s-indaceneAmyloid beta-Peptidesamyloid beta-protein (1-42)Boron CompoundsFluorescent DyesPeptide Fragmentsbiological imagingcentral nervous systemfluorescent probesrodent modelsβ-amyloid

Identifiers

PMID37523149
PMCPMC11468675
OpenAlexW4385407029

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.