Evidence map›Paper›PMID 37523101›Full record

ArticleMolecular diversity2024

Computational biology-based study of the molecular mechanism of spermidine amelioration of acute pancreatitis.

Yan Shen, Hongtao Duan, Lu Yuan, Aiminuer Asikaer, Yiyuan Liu, Rui Zhang, Yang Liu, Yuanqiang Wang, Zhihua Lin

Abstract read
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Article in Molecular diversity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yan Shen *Department of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 405400, China.
Hongtao Duan *Department of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 405400, China.
Lu YuanDepartment of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 405400, China.
Aiminuer AsikaerDepartment of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 405400, China.
Yiyuan LiuDepartment of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 405400, China.
Rui ZhangDepartment of Pharmacy, Guizhou Provincial People's Hospital, Guiyang, 550002, China.
Yang LiuDepartment of Hepatobiliary Surgery II, Guizhou Provincial People's Hospital, Guiyang, 550002, China.
Yuanqiang WangDepartment of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 405400, China.
Zhihua LinDepartment of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 405400, China. zhlin@cqut.edu.cn.
Chongqing University of Technology · CNGuizhou Provincial People's Hospital · CN

Funding

Chongqing University of Technology Postgraduate Quality Development Action Plan Funding Results gzlcx 20232115Guizhou Provincial Science and Technology Project No. QKHJC [2020]1Y382National Natural Science Foundation of China No. 82100684natural Science Foundation of Chongqing China CSTB2022NSCQ-MSX1493
6 · The paper itself

Abstract

Acute pancreatitis (AP) is an acute inflammatory gastrointestinal disease, the mortality and morbility of which has been on the increase in the past years. Spermidine, a natural polyamine, has a wide range of pharmacological effects including anti-inflammation, antioxidation, anti-aging, and anti-tumorigenic. This study aimed to investigate the reliable targets and molecular mechanisms of spermidine in treating AP. By employing computational biology methods including network pharmacology, molecular docking, and molecular dynamics (MD) simulations, we explored the potential targets of spermidine in improving AP with dietary supplementation. The computational biology results revealed that spermidine had high degrees (degree: 18, betweenness: 38.91; degree: 18, betweenness: 206.41) and stable binding free energy (ΔG

Indexed as

Molecular Docking SimulationMolecular Dynamics SimulationPancreatitisSpermidineAcetylcholinesteraseAcinar CellsAcute DiseaseAnimalsComputational BiologyMaleMiceNetwork PharmacologyAcetylcholinesteraseSpermidineAcute pancreatitisMolecular dockingMolecular dynamicsMolecular mechanismsSpermidine

Identifiers

PMID37523101
OpenAlexW4385403827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.