Evidence map›Paper›PMID 37523099›Full record

ArticleNeuroscience bulletin2023

Spatial Distribution of Parvalbumin-Positive Fibers in the Mouse Brain and Their Alterations in Mouse Models of Temporal Lobe Epilepsy and Parkinson's Disease.

Changgeng Song, Yan Zhao, Jiajia Zhang, Ziyi Dong, Xin Kang, Yuqi Pan, Jinle Du, Yiting Gao, Haifeng Zhang, Ye Xi and 10 more

Erratum issuedAbstract read
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In one paragraph

Article in Neuroscience bulletin, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Changgeng Song *Department of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Yan Zhao *Department of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Jiajia Zhang *National Translational Science Center for Molecular Medicine, Department of Cell Biology, Fourth Military Medical University, Xi'an, 710032, China.
Ziyi DongDepartment of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Xin KangDepartment of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Yuqi PanDepartment of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Jinle DuDepartment of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Yiting GaoDepartment of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Haifeng ZhangDepartment of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Ye XiDepartment of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Hui DingDepartment of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Fang KuangDepartment of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Wenting WangDepartment of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.ORCID http://orcid.org/0000-0002-8344-0102
Ceng LuoDepartment of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Zhengping ZhangDepartment of Spinal Surgery, Honghui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, 710054, China.
Qinpeng ZhaoDepartment of Spinal Surgery, Honghui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, 710054, China.
Jiazhou YangThe Medical College of Yan'an University, Yan'an, 716000, China.
Wen JiangDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. jiangwen@fmmu.edu.cn.
Shengxi WuDepartment of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China. shengxi@fmmu.edu.cn.
Fang GaoDepartment of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China. fanggao@fmmu.edu.cn.ORCID http://orcid.org/0000-0003-1099-8620

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parvalbumin interneurons belong to the major types of GABAergic interneurons. Although the distribution and pathological alterations of parvalbumin interneuron somata have been widely studied, the distribution and vulnerability of the neurites and fibers extending from parvalbumin interneurons have not been detailly interrogated. Through the Cre recombinase-reporter system, we visualized parvalbumin-positive fibers and thoroughly investigated their spatial distribution in the mouse brain. We found that parvalbumin fibers are widely distributed in the brain with specific morphological characteristics in different regions, among which the cortex and thalamus exhibited the most intense parvalbumin signals. In regions such as the striatum and optic tract, even long-range thick parvalbumin projections were detected. Furthermore, in mouse models of temporal lobe epilepsy and Parkinson's disease, parvalbumin fibers suffered both massive and subtle morphological alterations. Our study provides an overview of parvalbumin fibers in the brain and emphasizes the potential pathological implications of parvalbumin fiber alterations.

Indexed as

Epilepsy, Temporal LobeParkinson DiseaseAnimalsBrainDisease Models, AnimalInterneuronsMiceNeuronsParvalbuminsParvalbuminsNeuronal fiberParkinson’s diseaseParvalbumin interneuronPathological alterationSpatial distributionStatus epilepticusTemporal lobe epilepsy

Identifiers

PMID37523099
PMCPMC10603013

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.