Evidence map›Paper›PMID 37523076›Full record

ArticleAAPS PharmSciTech2023

A Pediatric Upper Airway Library to Evaluate Interpatient Variability of In Silico Aerosol Deposition.

Emily L Kolewe, Saurav Padhye, Ian R Woodward, Yu Feng, Jenna W Briddell, Catherine A Fromen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AAPS PharmSciTech, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emily L KoleweDepartment of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy St., Newark, Delaware, 19716, USA.
Saurav PadhyeDepartment of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy St., Newark, Delaware, 19716, USA.
Ian R WoodwardDepartment of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy St., Newark, Delaware, 19716, USA.
Yu FengDepartment of Chemical Engineering, Oklahoma State University, Stillwater, Oklahoma, USA.
Jenna W BriddellDivision of Otorhinolaryngology, Department of Surgery, Nemours Children's Hospital, Wilmington, Delaware, USA.
Catherine A FromenDepartment of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy St., Newark, Delaware, 19716, USA. cfromen@udel.edu.ORCID http://orcid.org/0000-0002-7528-0997

Funding

Multiscale considerations for immune engineering at mucosal interfacesR35GM142866 · NIGMS · UNIVERSITY OF DELAWARE · PI Catherine A Fromen · 2021 to 2026
$2.4M
Dynamic, Cellularized, 3D Printed Model Development for Aerosol Targeting in Pediatric JORRP PatientsF31HL160153 · NHLBI · UNIVERSITY OF DELAWARE · PI KOLEWE, EMILY · 2021 to 2022
$60k
NHLBI NIH HHS F31 HL160153NIGMS NIH HHS R35 GM142866
6 · The paper itself

Abstract

The airway of pediatric patients' changes through development, presenting a challenge in developing pediatric-specific aerosol therapeutics. Our work aims to quantify geometric variations and aerosol deposition patterns during upper airway development in subjects between 3.5 months-6.9 years old using a library of 24 pediatric models and 4 adult models. Computational fluid-particle dynamics was performed with varying particle size (0.1-10 μm) and flow rate (10-120 Lpm), which was rigorously analyzed to compare anatomical metrics (epiglottis angle (θ

Indexed as

NoseTracheaAdministration, InhalationAdultAerosolsChildComputer SimulationHumansLungNebulizers and VaporizersParticle SizeAerosolsaerosolanatomical developmentCFPDinterpatient variabilitypediatric

Identifiers

PMID37523076
PMCPMC10660588

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.