Evidence map›Paper›PMID 37523074›Full record

ArticleIndian journal of pediatrics2024

Umbilical Cord Blood IgA Levels and Bacterial Profile in Preterm Neonates Born with Maternal Risk Factors for Early-Onset Neonatal Sepsis.

Ashish Jain, Kajal Jain, Divashree Jhurani, Asha Mishra, Sarita Mohapatra, Akash Sharma, Vikas Manchanda, M Jeeva Sankar, Ramesh Agarwal

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Article in Indian journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

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3 · Its place in the literature

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0 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ashish JainDepartment of Neonatology, Central Health Service, Maulana Azad Medical College, (University of Delhi), Govt. of India, New Delhi, India.
Kajal JainDepartment of Pediatrics, WHO Collaborating Centre for Education and Research in Newborn Health, Newborn Health Knowledge Centre, All India Institute of Medical Sciences, New Delhi, 110029, India. kajaljain12@gmail.com.ORCID 0000-0003-3504-6773
Divashree JhuraniDepartment of Pediatrics, WHO Collaborating Centre for Education and Research in Newborn Health, Newborn Health Knowledge Centre, All India Institute of Medical Sciences, New Delhi, 110029, India.
Asha MishraDepartment of Gastroenterology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Sarita MohapatraDepartment of Microbiology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Akash SharmaDepartment of Pediatrics, WHO Collaborating Centre for Education and Research in Newborn Health, Newborn Health Knowledge Centre, All India Institute of Medical Sciences, New Delhi, 110029, India.
Vikas ManchandaDepartment of Microbiology, Central Health Service, Maulana Azad Medical College, (University of Delhi), Govt. of India, New Delhi, India.
M Jeeva SankarDepartment of Pediatrics, WHO Collaborating Centre for Education and Research in Newborn Health, Newborn Health Knowledge Centre, All India Institute of Medical Sciences, New Delhi, 110029, India.
Ramesh AgarwalDepartment of Pediatrics, WHO Collaborating Centre for Education and Research in Newborn Health, Newborn Health Knowledge Centre, All India Institute of Medical Sciences, New Delhi, 110029, India.
All India Institute of Medical Sciences · INUniversity of Delhi · IN

Funding

All-India Institute of Medical Sciences F.8-526/A-526/2017/RS
6 · The paper itself

Abstract

objectivesTo investigate the IgA levels and bacterial profile in umbilical cord blood (UCB) samples of mothers with risk factors compared to those without risk factors; and to understand the link between UCB culture positivity and neonatal outcomes [early-onset sepsis (EOS) or death within 7 d of life].

methodsThis is a pilot prospective case-control study. Mothers with preterm deliveries (gestational age <34 wk) were enrolled in two groups- Cases: Those with antenatal risk factors (prolonged duration of rupture of membranes of ≥24 h or chorioamnionitis) and controls: Those without these two risk factors. Serum IgA levels was assayed and microbiological culture was tested in UCB samples. 16S sequencing to determine the UCB microbiome was performed in a subset of samples (n = 15). Neonates were followed-up for the occurrence of EOS or death until 7 d of life.

resultsForty-nine mothers as cases and 50 mothers as controls were consecutively enrolled. No significant difference was observed in the IgA levels (60.5 vs. 58.1 mg/L; p = 0.71), neonatal blood culture positivity (4.1% vs. 8.0%; p = 0.41) and UCB culture positivity (30.6% vs. 26.0%; p = 0.61) in the two groups. No difference was observed between the groups in occurrence of EOS or death within 7 d of life. Proteobacteria, Firmicutes and Actinobacteria were the most abundant phyla. Serratia, Bifidobacterium, Collinsella, Meganomas and Blautia being the most common genera.

conclusionsCord blood IgA concentration could not differentiate the neonates at-risk of infection due to its presence in both the groups.

Indexed as

Fetal BloodImmunoglobulin AInfant, PrematureNeonatal SepsisAdultCase-Control StudiesChorioamnionitisFemaleHumansInfant, NewbornMalePilot ProjectsPregnancyProspective StudiesRisk FactorsImmunoglobulin A16S rRNAIgANeonatal sepsisUmbilical cord blood

Identifiers

PMID37523074
OpenAlexW4385406083

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.