ArticleThe EMBO journal2023
Embryo-uterine interaction coordinates mouse embryogenesis during implantation.
Article in The EMBO journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 36 citations in OpenAlex.
- Elevated contractility drives implantation failure in mouse embryos from aged females.Nature cell biology · 2026Article
- From Static to Dynamic: Fluorescence Imaging Technology Advances Precise Embryo Evaluation.Small methods · 2026Review
- Modeling human embryo adhesion using a microfluidic platform.Science advances · 2026Article
- Boundary geometry controls a topological defect transition that determines lumen nucleation in embryonic development.Nature materials · 2026Article
- Mechanical cues regulateMaterials today. Bio · 2026Article
- Synthetic data enables human-grade microtubule analysis with foundation models for segmentation.PLoS computational biology · 2026Article
- Synthetic embryos: current progress, application and challenges.Reproductive biology and endocrinology : RB&E · 2026Review
- High-Fidelity Long-term Whole-embryo Lineage and Fate Reconstruction by Iterative Tracking with Error Correction.bioRxiv : the preprint server for biology · 2026Article
- HIF2α-induced lysyl oxidase safeguards successful pregnancy by remodelling collagens at the feto-maternal interface.Cell death & disease · 2026Article
- Back to the Future-A 50-Year Dive into Embryo Implantation Research: Cell Biological Paradox, Epithelial Cell Polarity, and EMT.Biomolecules · 2026Review
- Trophectoderm-like cells from EPS cells enable generating EPS cell-derived post-implantation embryoids that complete gastrulation.Protein & cell · 2026Article
- In Vitro Hatching ofInternational journal of molecular sciences · 2026Article
- Modelling mammalian implantationAnimal reproduction · 2026Review
- Boundary-guided cell alignment drives mouse epiblast maturation.Nature physics · 2026Article
- Advances and challenges of endometrial organoids in modeling endometrial function: basic, clinical, and future perspectives.Frontiers in bioengineering and biotechnology · 2026Review
- Review
- A mechanical origin for implantation defects in embryos from aged females.bioRxiv : the preprint server for biology · 2025Article
- Traction force and mechanosensitivity mediate species-specific implantation patterns in human and mouse embryos.Science advances · 2025Article
- An ex vivo uterine system captures implantation, embryogenesis, and trophoblast invasion via maternal-embryonic signaling.Nature communications · 2025Article
- Maternal intestinal L. vaginalis facilitates embryo implantation and survival through enhancing uterine receptivity in sows.Microbiome · 2025Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Embryo implantation into the uterus marks a key transition in mammalian development. In mice, implantation is mediated by the trophoblast and is accompanied by a morphological transition from the blastocyst to the egg cylinder. However, the roles of trophoblast-uterine interactions in embryo morphogenesis during implantation are poorly understood due to inaccessibility in utero and the remaining challenges to recapitulate it ex vivo from the blastocyst. Here, we engineer a uterus-like microenvironment to recapitulate peri-implantation development of the whole mouse embryo ex vivo and reveal essential roles of the physical embryo-uterine interaction. We demonstrate that adhesion between the trophoblast and the uterine matrix is required for in utero-like transition of the blastocyst to the egg cylinder. Modeling the implanting embryo as a wetting droplet links embryo shape dynamics to the underlying changes in trophoblast adhesion and suggests that the adhesion-mediated tension release facilitates egg cylinder formation. Light-sheet live imaging and the experimental control of the engineered uterine geometry and trophoblast velocity uncovers the coordination between trophoblast motility and embryo growth, where the trophoblast delineates space for embryo morphogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.