ArticleAngewandte Chemie (International ed. in English)2023
Efficient Synthesis of Hydrolytically Degradable Block Copolymer Nanoparticles via Reverse Sequence Polymerization-Induced Self-Assembly in Aqueous Media.
Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Synthesis of Poly(δ-valerolactone)-poly(Macromolecules · 2026Article
- Time-Resolved SAXS Studies During the Synthesis of Hydrolytically Degradable Poly(ε-caprolactone)-Poly(N,N'-dimethylacrylamide) Diblock Copolymer Nanoparticles in Aqueous Media.Angewandte Chemie (International ed. in English) · 2026Article
- Deciphering Evolution, Function, and Observation of Crystallization-Driven Self-Assembly.Chemical reviews · 2025Review
- Boron-Rich Soft Hydrogels Based on the Coassembly of Cationic A‑B‑A Triblock Copolymers withMacromolecules · 2025Article
- Combining Crystallization-Driven Self-Assembly with Reverse Sequence Polymerization-Induced Self-Assembly Enables the Efficient Synthesis of Hydrolytically Degradable Anisotropic Block Copolymer Nano-objects Directly in Concentrated Aqueous Media.Journal of the American Chemical Society · 2024Article
- Synthesis of Poly(propylene oxide)-Poly(Macromolecules · 2024Article
- Efficient Synthesis of Hydrolytically Degradable Block Copolymer Nanoparticles via Reverse Sequence Polymerization-Induced Self-Assembly in Aqueous Media.Angewandte Chemie (International ed. in English) · 2023Article
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Authors and funding
3 authors.
Funding
Abstract
Hydrolytically degradable block copolymer nanoparticles are prepared via reverse sequence polymerization-induced self-assembly (PISA) in aqueous media. This efficient protocol involves the reversible addition-fragmentation chain transfer (RAFT) polymerization of N,N'-dimethylacrylamide (DMAC) using a monofunctional or bifunctional trithiocarbonate-capped poly(ϵ-caprolactone) (PCL) precursor. DMAC monomer is employed as a co-solvent to solubilize the hydrophobic PCL chains. At an intermediate DMAC conversion of 20-60 %, the reaction mixture is diluted with water to 10-25 % w/w solids. The growing amphiphilic block copolymer chains undergo nucleation to form sterically-stabilized PCL-core nanoparticles with PDMAC coronas.
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