ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023
Microstructural and Rheological Transitions in Bacterial Biofilms.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- Sporulation modulates viscoelastic development through extracellular matrix restructuring inbioRxiv : the preprint server for biology · 2026Article
- Production and partial characterization of fructose-rich exopolysaccharide from a newly isolated halophilic strain Vreelandella sp. DT-Z4.BMC biotechnology · 2026Article
- The EPS-I exopolysaccharide transformsProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Assembling Hexahedral Supramolecular Nano-Aggregates on Rice Wax Layer Matrices to Promote the Leaf Deposition and Bioavailability of Bactericides for Plant Protections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Elastic Deformation of Cellulose/Lignin-Based Anode for Rejuvenating Aged Mix-Cultured Electroactive Biofilms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Bacteria Colonies Modify Their Shear and Compressive Mechanical Properties in Response to Different Growth Substrates.ACS applied bio materials · 2024Article
- Article
- Yielding behaviour of chemically treatedBiofilm · 2024Article
- Microstructural and Rheological Transitions in Bacterial Biofilms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Biofilms are aggregated bacterial communities structured within an extracellular matrix (ECM). ECM controls biofilm architecture and confers mechanical resistance against shear forces. From a physical perspective, biofilms can be described as colloidal gels, where bacterial cells are analogous to colloidal particles distributed in the polymeric ECM. However, the influence of the ECM in altering the cellular packing fraction (ϕ) and the resulting viscoelastic behavior of biofilm remains unexplored. Using biofilms of Pantoea sp. (WT) and its mutant (ΔUDP), the correlation between biofilm structure and its viscoelastic response is investigated. Experiments show that the reduction of exopolysaccharide production in ΔUDP biofilms corresponds with a seven-fold increase in ϕ, resulting in a colloidal glass-like structure. Consequently, the rheological signatures become altered, with the WT behaving like a weak gel, whilst the ΔUDP displayed a glass-like rheological signature. By co-culturing the two strains, biofilm ϕ is modulated which allows us to explore the structural changes and capture a change in viscoelastic response from a weak to a strong gel, and to a colloidal glass-like state. The results reveal the role of exopolysaccharide in mediating a structural transition in biofilms and demonstrate a correlation between biofilm structure and viscoelastic response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.