Evidence map›Paper›PMID 37522607›Full record

ArticleJournal of analytical toxicology2023

The impact of vaping ethanol-containing electronic cigarette liquids on roadside impairment investigations.

Alaina K Holt, Akansha Anbil, Madison M Combs, Erica R Sales, Edward L Boone, Justin L Poklis, Edgar L Greer, Nareg Karaoghlanian, Alison B Breland, Michelle R Peace

Open access · greenAbstract read
In one paragraph

Article in Journal of analytical toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Interpol review of forensic toxicology, 2023-2025.Forensic science international. Synergy · 2026
    Review
  3. Ethyl acetate in e-liquids: Implications for breath testing.Journal of analytical toxicology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Alaina K HoltDepartment of Forensic Science, Virginia Commonwealth University, 1015 W Main Street, Room 2015, Richmond, VA 23284, United States.ORCID 0000-0002-0474-6622
Akansha AnbilDepartment of Psychology, Virginia Commonwealth University, 806 W Franklin Street, PO Box 842018, Richmond, VA 23284, United States.
Madison M CombsDepartment of Psychology, Virginia Commonwealth University, 806 W Franklin Street, PO Box 842018, Richmond, VA 23284, United States.
Erica R SalesDepartment of Forensic Science, Virginia Commonwealth University, 1015 W Main Street, Room 2015, Richmond, VA 23284, United States.
Edward L BooneDepartment of Statistical Sciences & Operations Research, Virginia Commonwealth University, 1015 Floyd Avenue, PO Box 843083, Richmond, VA 23284, United States.
Justin L PoklisDepartment of Pharmacology & Toxicology, Virginia Commonwealth University, 1112 East Clay Street, PO Box 980613, Richmond, VA 23298, United States.ORCID 0000-0001-5470-5717
Edgar L GreerVirginia Commonwealth University Police Department, 224 East Broad Street, Richmond, VA 23219, United States.
Nareg KaraoghlanianMaroun Semaan Faculty of Engineering and Architecture, American University of Beirut, PO Box 11-0236, Riad El-Solh 1107 2020, Beirut, Lebanon.ORCID 0000-0002-3553-7233
Alison B BrelandDepartment of Psychology, Virginia Commonwealth University, 806 W Franklin Street, PO Box 842018, Richmond, VA 23284, United States.
Michelle R PeaceDepartment of Forensic Science, Virginia Commonwealth University, 1015 W Main Street, Room 2015, Richmond, VA 23284, United States.ORCID 0000-0002-1480-139X
Virginia Commonwealth University · USAmerican University of Beirut · LB

Funding

Project 4: Using a prospective cohort survey to test population-level predictions generated by Projects 1-3U54DA036105 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI FAGAN, PEBBLES · 2018 to 2022
$20.8M
VCU Center for Drug Addiction ResearchP30DA033934 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI JOLENE J WINDLE · 2014 to 2026
$13.8M
NIDA NIH HHS P30 DA033934 U54DA036105NIDA NIH HHS U54 DA036105
6 · The paper itself

Abstract

Legal professionals and others have suggested that vaping electronic cigarettes (e-cigs) prior to or during ethanol breath testing may produce false positives. Preliminary breath tests (PBTs) and evidentiary breath tests (EBTs) measure ethanol in exhaled breath and standardized field sobriety tests (SFSTs) are used to assess impairment. Ethanol has been identified in e-cig liquids (e-liquids). Presented are a series of experiments designed to determine the mechanics of vaping ethanol using an e-cig and the effects of vaping ethanol on the SFSTs and breath tests used by law enforcement officers (LEO). Twelve participants (five females, age: 21-32 and seven males, age: 21-55), vaped either one or ten puffs of an e-liquid (0% or 20% ethanol). LEOs assessed impairment using SFSTs (12 and 42 min), PBTs (<1, 27, 32, 37 and 57 min) and EBTs (2, 29, 34, 39 and 59 min) post-vaping. A self-assessment test was administered post-vaping (22 and 52 min). Baseline responses for all measures were collected prior to vaping. Results demonstrated that ethanol in the e-liquids was aerosolized by e-cigs and produced particles that could reach the deep lung tissue based on mean-mass diameter. Ethanol was detected by PBT <3 min after participants vaped one (0.007-0.030 g/210 L) or ten puffs (013-0.074 g/210 L) of a 20% ethanol e-liquid. Ethanol was not detected by PBT at any subsequent time point. Ethanol was not detected by the EBT under any condition. Impairment was not indicated by the SFST. Some subjective effects were reported, but few statistically significant differences between conditions were indicated. A wait period prior to ethanol breath testing is not always mandated, depending on jurisdiction, or observed in all applications, such as workplace testing. The results demonstrate that a wait period must be employed to prevent vaping-related false-positive breath ethanol results.

Indexed as

Electronic Nicotine Delivery SystemsVapingAdultBreath TestsFemaleHumansLungMaleMiddle AgedYoung Adult

Identifiers

PMID37522607
PMCPMC10627344
OpenAlexW4385406733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.