Evidence map›Paper›PMID 37522277›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2023

The right hemisphere's capacity for language: evidence from primary progressive aphasia.

Kyriaki Neophytou, Robert Wiley, Celia Litovsky, Kyrana Tsapkini, Brenda Rapp

Abstract read
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Cerebello-Cerebral Pathways Contribute to Written Word Production.Neurobiology of language (Cambridge, Mass.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kyriaki NeophytouDepartment of Neurology, Johns Hopkins Medicine, Baltimore, MD, United States.
Robert WileyDepartment of Psychology, University of North Carolina at Greensboro, Greensboro, NC, United States.
Celia LitovskyDepartment of Cognitive Science, Johns Hopkins University, Baltimore, MD, United States.
Kyrana TsapkiniDepartment of Neurology, Johns Hopkins Medicine, Baltimore, MD, United States.
Brenda RappDepartment of Cognitive Science, Johns Hopkins University, Baltimore, MD, United States.

Funding

Project 2 MeasurementU19AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI Mei Cheng Wang · 2014 to 2026
$51.5M
Biomarkers of Cognitive Decline among Normal Individuals: The BIOCARD cohortU01AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S. · 2009 to 2013
$11.2M
Effects of transcranial direct current stimulation in spoken and written production in primary progressive aphasiaR01DC014475 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI TSAPKINI, KYRANA · 2015 to 2019
$4.1M
Targeting language-specific and executive-control networks with transcranial direct current stimulation in aphasic ADR01AG075404 · NIA · JOHNS HOPKINS UNIVERSITY · PI Kyrana Tsapkini · 2022 to 2026
$4.0M
Transcranial direct current stimulation in typical and atypical Alzheimer's diseaseR01AG068881 · NIA · JOHNS HOPKINS UNIVERSITY · PI TSAPKINI, KYRANA · 2020 to 2024
$3.8M
Neuroimaging--Treatment and Recovery of Written LanguageR01DC006740 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI RAPP, BRENDA C · 2004 to 2008
$2.6M
NIA NIH HHS R01 AG068881NIA NIH HHS R01 AG075404NIA NIH HHS U01 AG033655NIA NIH HHS U19 AG033655NIDCD NIH HHS R01 DC006740NIDCD NIH HHS R01 DC014475
6 · The paper itself

Abstract

The role of the right hemisphere (RH) in core language processes is still a matter of intense debate. Most of the relevant evidence has come from studies of gray matter, with relatively little research on RH white matter (WM) connectivity. Using Diffusion Tensor Imaging-based tractography, the current work examined the role of the two hemispheres in language processing in 33 individuals with Primary Progressive Aphasia (PPA), aiming to better characterize the contribution of the RH to language processing in the context of left hemisphere (LH) damage. The findings confirm the impact of PPA on the integrity of the WM language tracts in the LH. Additionally, an examination of the relationship between tract integrity and language behaviors provides robust evidence of the involvement of the WM language tracts of both hemispheres in language processing in PPA. Importantly, this study provides novel evidence of a unique contribution of the RH to language processing (i.e. a contribution independent from that of the language-dominant LH). Finally, we provide evidence that the RH contribution is specific to language processing rather than being domain general. These findings allow us to better characterize the role of RH in language processing, particularly in the context of LH damage.

Indexed as

Aphasia, Primary ProgressiveWhite MatterDiffusion Tensor ImagingGray MatterHumansLanguagediffusion tensor imaginglanguage lateralizationprimary progressive aphasiaright hemispherewhite matter tracts

Identifiers

PMID37522277
PMCPMC10502784

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.