ArticleJournal of the American Heart Association2023
Bidirectional Association Between Frailty and Cardiac Structure and Function: The Atherosclerosis Risk in Communities Study.
Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Effects of intraoperative open-lung strategy on cardiopulmonary function in frail elderly patients undergoing laparoscopic surgery: a randomized controlled trial.BMC surgery · 2025Trial
- Longitudinal Changes in Frailty and Major Adverse Cardiovascular Events in Patients With Coronary Heart Disease.Journal of the American Heart Association · 2026Article
- Frailty and Echocardiographic Indices of Diastolic Function in Older Adults: A Cross-Sectional Analysis.Journal of clinical medicine · 2026Article
- Sex-specific associations of physical frailty with cardiac structure and function: a cross-sectional study based on UK Biobank.BMC cardiovascular disorders · 2026Article
- The Impact of Frailty on Left Ventricle Mass and Geometry in Elderly Patients with Normal Ejection Fraction: A STROBE-Compliant Cross-Sectional Study.Journal of cardiovascular development and disease · 2026Article
- Untangling the prognostic value of diastolic dysfunction, NT-proBNP, and frailty in older patients with preserved left ventricular ejection fraction without valvular disease.BMC geriatrics · 2025Observational
- Overcoming Implementation Barriers in Frailty Management in Cardiology: From Consensus to Bedside.JACC. Asia · 2025Article
- Association between frailty and echocardiographic findings in hospitalized older adults with preserved ejection fraction.European heart journal open · 2025Article
- Prevent Frailty, Prevent Cardiovascular Disease: Early Identification of Patients at Risk.JACC. Advances · 2025Article
- Whole-Body MRI for Assessment of Physical Frailty.Journal of magnetic resonance imaging : JMRI · 2025Article
- Heart Failure in Older Patients: An Update.Journal of clinical medicine · 2025Review
- Association of left atrial function with frailty: The Atherosclerosis Risk in Communities (ARIC) study.Journal of the American Geriatrics Society · 2024Article
- Unsuccessful ageing: from frailty to cardiovascular disease.European heart journal · 2024Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Background Frailty and heart failure frequently coexist in late life. Limited data exist regarding the longitudinal associations of frailty and subclinical cardiac dysfunction. We aim to quantify the association of frailty with longitudinal changes in cardiac function and of cardiac function with progression in frailty status in older adults. Methods and Results Participants in the Atherosclerosis Risk in Communities cohort underwent frailty assessments at Visit 5 (V5; 2011-2013), V6 (2016-2017), and V7 (2018-2019), and echocardiographic assessments at V5 and V7. We assessed the association between frailty status at V5 and changes in frailty status from V5 to V7 and changes in cardiac function over 6 years. We then evaluated the association of cardiac function measured at Visit 5 with progression in frailty status over 4 years. Multivariable regression models adjusted for demographics and comorbidities. Among 2574 participants free of heart failure at V5 and V7 (age 74±4 years at V5 and 81±4 years at V7), 3% (n=83) were frail. Frailty at V5 was associated with greater left atrial volume index and E/e' ratio at V5 and 7. Participants who transitioned from robust at V5 to frail at V7 demonstrated greater increases in left ventricular mass index, left atrial volume index, and E/e' over the same period. Among 1648 robust participants at Visit 5, greater left ventricular mass index and mean wall thickness, lower tissue Doppler imaging e', and higher E/e' ratio at Visit 5 were associated with progression in frailty status. Conclusions Among robust, older adults free of heart failure, progression in frailty and subclinical left ventricular remodeling and diastolic dysfunction are interrelated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.