Evidence map›Paper›PMID 37521713›Full record

ArticleJournal of obsessive-compulsive and related disorders2023

Obsessive-compulsive disorder in youth and young adults with depression: Clinical characteristics of comorbid presentations.

David B Riddle, Andrew Guzick, Abu Minhajuddin, Orri Smárason, Gabrielle M Armstrong, Holli Slater, Taryn L Mayes, Lynnel C Goodman, Denise L Baughn, Sarah L Martin and 6 more

Open access · greenAbstract read
In one paragraph

Article in Journal of obsessive-compulsive and related disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

David B RiddleMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
Andrew GuzickMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
Abu MinhajuddinPeter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Orri SmárasonMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
Gabrielle M ArmstrongMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
Holli SlaterDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Taryn L MayesDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Lynnel C GoodmanDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Denise L BaughnDepartment of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX, USA.
Sarah L MartinDepartment of Psychiatry, Texas Tech University Health Science Center, Lubbock, TX, USA.
Sarah M WakefieldDepartment of Psychiatry, Texas Tech University Health Science Center, Lubbock, TX, USA.
Joseph BladerUniversity of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Ryan BrownDepartment of Psychiatry and Behavioral Sciences, University of Texas, Austin, TX, USA.
Wayne K GoodmanMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
Madhukar H TrivediPeter O'Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Eric A StorchMenninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
Baylor College of Medicine · USThe University of Texas Southwestern Medical Center · USTexas Tech University · USThe University of Texas at Austin · USThe University of Texas Health Science Center at San Antonio · USThe University of Texas Medical Branch at Galveston · US

Funding

Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
NICHD NIH HHS P50 HD103555
6 · The paper itself

Abstract

Obsessive-compulsive disorder (OCD), anxiety disorders, and depressive disorders are highly comorbid, and each contribute to significant functional impairment for affected youth. Comorbid anxiety disorders in depressed youth have been associated with greater depressive symptom severity and impairment, but the impact of comorbid OCD in this population remains unclear. Accordingly, the present study examined the differential clinical characteristics of youth with depression and comorbid OCD relative to age/gender matched depressed youth with no such comorbidity and to those with depression and a comorbid (non-OCD) anxiety disorder. A sample of 797 youth and young adults ages 8-20 years who met diagnostic criteria for depression alone, depression with co-occurring OCD or any anxiety disorder were included in the present study. Rates of comorbid anxiety and OCD were very high (60.5% and 15.5%, respectively). Relative to youth with only depression, depressed youth with comorbid OCD or anxiety had greater severity of depression, suicidality, and overall impairment in social, physical, and emotional functioning. These results highlight the contribution of OCD or anxiety comorbidity in more complex clinical presentations for depressed youth.

Indexed as

AdolescentsAnxietyAssessmentChildrenComorbidityDepressionObsessive-compulsive disorder

Identifiers

PMID37521713
PMCPMC10373162
OpenAlexW4379654712

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.