Evidence map›Paper›PMID 37521712›Full record

ArticleJournal of obsessive-compulsive and related disorders2023

Failures of Urge Suppression in Obsessive-Compulsive Disorder: Behavioral Modeling Using a Blink Suppression Task.

Laura B Bragdon, Jacob A Nota, Goi Khia Eng, Nicolette Recchia, Pearl Kravets, Katherine A Collins, Emily R Stern

Abstract read
In one paragraph

Article in Journal of obsessive-compulsive and related disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laura B BragdonDepartment of Psychiatry, New York University School of Medicine.
Jacob A NotaDepartment of Psychiatry, McLean Hospital, Harvard Medical School.
Goi Khia EngDepartment of Psychiatry, New York University School of Medicine.
Nicolette RecchiaDepartment of Psychiatry, New York University School of Medicine.
Pearl KravetsDepartment of Psychiatry, New York University School of Medicine.
Katherine A CollinsNathan Kline Institute for Psychiatric Research.
Emily R SternDepartment of Psychiatry, New York University School of Medicine.

Funding

Neurobiology of sensory phenomena in obsessive-compulsive disorderR01MH111794 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI STERN, EMILY R · 2017 to 2021
$3.0M
The effects of ondansetron on neural systems and symptoms associated with sensory phenomenaR33MH107589 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI STERN, EMILY R · 2017 to 2019
$1.4M
The effects of ondansetron on neural systems and symptoms associated with sensory phenomenaR21MH107589 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI STERN, EMILY R · 2015 to 2016
$922k
NIMH NIH HHS R01 MH111794NIMH NIH HHS R21 MH107589NIMH NIH HHS R33 MH107589
6 · The paper itself

Abstract

Many individuals with obsessive-compulsive disorder (OCD) report sensory-based urges (e.g. 'not-just-right experiences') in addition to, or instead of, concrete fear-based obsessions. These sensations may be comparable to normative "urges-for-action" (UFA), such as the urge to blink. While research has identified altered functioning of brain regions related to UFA in OCD, little is known about behavioral patterns of urge suppression in the disorder. Using an urge-to-blink task as a model for sensory-based urges, this study compared failures of urge suppression between OCD patients and controls by measuring eyeblinks during 60-second blocks of instructed blink suppression. Cox shared frailty models estimated the hazard of first blinks during each 60-second block and recurrent blinks following each initial erroneous blink. OCD patients demonstrated a higher hazard of first and recurrent blinks compared to controls, suggesting greater difficulty resisting repetitive sensory-based urges. Within OCD, relationships between task outcomes and symptom severity were inconsistent. Findings provide support for a deficit in delaying initial urge-induced actions and terminating subsequent actions in OCD, which is not clearly related to clinical heterogeneity. Elucidating the nature of behavioral resistance to urges is relevant for informing conceptualizations of obsessive-compulsive psychopathology and optimizing treatment outcomes.

Indexed as

compulsivityobsessive-compulsive disordersensory phenomena

Identifiers

PMID37521712
PMCPMC10373599

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.