Evidence map›Paper›PMID 37521635›Full record

ArticleACS omega2023

Structural Conformation and Activity of Spider-Derived Inhibitory Cystine Knot Peptide Pn3a Are Modulated by pH.

Poanna Tran, Theo Crawford, Lotten Ragnarsson, Jennifer R Deuis, Mehdi Mobli, Simon J Sharpe, Christina I Schroeder, Irina Vetter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Structural Basis of the Bivalency of the TRPV1 Agonist DkTx.Angewandte Chemie (International ed. in English) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Poanna TranInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.ORCID https://orcid.org/0000-0003-3196-9896
Theo CrawfordCentre for Advanced Imaging, The University of Queensland, Brisbane, Queensland 4072, Australia.ORCID https://orcid.org/0000-0002-1101-5705
Lotten RagnarssonInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Jennifer R DeuisInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Mehdi MobliCentre for Advanced Imaging, The University of Queensland, Brisbane, Queensland 4072, Australia.
Simon J SharpeMolecular Medicine Program, Research Institute, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.
Christina I SchroederInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.ORCID https://orcid.org/0000-0002-6737-6374
Irina VetterInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.ORCID https://orcid.org/0000-0002-3594-9588

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous spider venom-derived gating modifier toxins exhibit conformational heterogeneity during purification by reversed-phase high-performance liquid chromatography (RP-HPLC). This conformational exchange is especially peculiar for peptides containing an inhibitor cystine knot motif, which confers excellent structural stability under conditions that are not conducive to disulfide shuffling. This phenomenon is often attributed to proline

Identifiers

PMID37521635
PMCPMC10373202

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.