Evidence map›Paper›PMID 37521442›Full record

ArticleHuman gene (Amsterdam, Netherlands)2022

Association of Toll-like receptor-4 polymorphism with SARS CoV-2 infection in Kurdish Population.

Hussein N Ali, Sherko S Niranji, Sirwan M A Al-Jaf

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human gene (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hussein N AliCollege of Medicine, University of Garmian, Kurdistan region, Iraq.
Sherko S NiranjiCollege of Medicine, University of Garmian, Kurdistan region, Iraq.
Sirwan M A Al-JafCollege of Medicine, University of Garmian, Kurdistan region, Iraq.
University of Garmian

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic variations are critical for understanding clinical outcomes of infections including server acute respiratory syndrome coronavirus 2 (SARS CoV-2). The immunological reactions of human immune genes with SARS CoV-2 have been under investigation. Toll-like receptors (TLRs), a group of proteins, are important for microbial detections including bacteria and viruses. TLR4 can sense both bacterial lipopolysaccharides (LPS) and endogenous oxidized phospholipids triggered by Covid-19 infection. Two TLR4 single nucleotide polymorphisms (SNPs), Asp299Gly and Thr399Ile have been linked to infectious diseases. No studies have focused on these SNPs in association with Covid-19. This study aims to reveal the association between Covid-19 infection with these SNPs by comparing a group of patients and a general population. Restriction fragment length polymorphisms (RFLP) were used to identify the TLR4 SNPs in both the general population (

Indexed as

ACE2, Angiotensin converting enzyme 2ARSD, Acute respiratory distress syndromeCovid-19Covid-19, Coronavirus disease 2019IL, InterleukinLPS, Lipopolysaccharides (LPS)MyD88, Myeloid differentiation factorPCR-RFLP, Polymerase chain reaction-restriction fragment polymorphismpolymorphismSARS CoV-2SARS CoV-2, Server acute respiratory syndrome coronavirus 2SNPSNPs, Single nucleotide polymorphismsTLR4TLRs, Toll-like receptorsTNF-α, Tumour necrosis factor alpha;TRIF, TIR-domain-containing adapter-inducing interferon-β.

Identifiers

PMID37521442
PMCPMC9529343
OpenAlexW4300772631

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.