ArticleFrontiers in medicine2023
Adverse pregnancy outcomes and associated risk factors among pregnant women with syphilis during 2013-2018 in Hunan, China.
Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.
- prevalence of syphilis among pregnant women in China: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Factors associated with preterm birth and low birth weight among syphilis-infected pregnant women.BMC infectious diseases · 2026Article
- Factors related to adverse pregnancy outcomes of maternal syphilis in Nanning, Guangxi, China 2016-2020.Scientific reports · 2025Article
- Congenital Syphilis: A Re-Emerging but Preventable Infection.Pathogens (Basel, Switzerland) · 2024Review
- Gestational syphilis in a tertiary health service in Paraná, Brazil: A case-control study.PloS one · 2024Article
- Congenital Syphilis-An Illustrative Review.Children (Basel, Switzerland) · 2023Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
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Abstract
Objective: To investigate the adverse pregnancy outcomes and associated risk factors among pregnant women with syphilis. Design: Pregnant women with syphilis in the registry for the prevention of mother-to-child transmission of AIDS, syphilis and hepatitis B in Hunan Province, China, from January 1, 2013 to December 31, 2018 were included in the study. Results: Among the 14,219 pregnant women with syphilis, 11,346 had definite pregnancy outcomes and were in singleton pregnancy. The risk factors related to adverse pregnancy outcomes include the age of pregnant women with syphilis <20 years old (aOR = 1.274, 95% CI: 1.088-1.493) or ≥ 35 years old (aOR = 1.402, 95% CI: 1.167-1.686), not married (aOR = 1.855, 95% CI: 1.453-2.367), initial syphilis detection in the late pregnancy (aOR = 1.266, 95% CI: 1.032-1.555), diagnosis of syphilis in the late pregnancy (aOR = 5.806, 95% CI: 1.796-18.770), diagnosis of syphilis during labor (aOR = 4.102, 95% CI: 1.263-13.330), husband/sexual partner infected with syphilis (aOR = 1.222, 95% CI: 1.068-1.398), untreated (aOR = 6.756, 95% CI: 5.586-8.197), and nonstandard medication (aOR = 3.300, 95% CI: 2.841-3.846). Conclusion: The prevalence of adverse pregnancy outcomes among pregnant women with syphilis in Hunan Province, China from 2013 to 2018 was relatively high. The adverse pregnancy outcomes associated with syphilis could be reduced by early detection and standard treatment of syphilis for pregnant women and their husbands/sexual partners.
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