Evidence map›Paper›PMID 37521052›Full record

ArticlePatterns (New York, N.Y.)2023

Connectome-based machine learning models are vulnerable to subtle data manipulations.

Matthew Rosenblatt, Raimundo X Rodriguez, Margaret L Westwater, Wei Dai, Corey Horien, Abigail S Greene, R Todd Constable, Stephanie Noble, Dustin Scheinost

Open access · goldAbstract read
In one paragraph

Article in Patterns (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Embracing Model Heterogeneity for Better Brain-Behavior Associations.Biological psychiatry global open science · 2025
    Article
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  8. Article
  9. Review
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Matthew RosenblattDepartment of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT 06510, USA.
Raimundo X RodriguezInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06510, USA.
Margaret L WestwaterDepartment of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, CT 06510, USA.
Wei DaiDepartment of Biostatistics, Yale School of Public Health, New Haven, CT 06510, USA.
Corey HorienInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06510, USA.
Abigail S GreeneInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06510, USA.
R Todd ConstableDepartment of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT 06510, USA.
Stephanie NobleDepartment of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, CT 06510, USA.
Dustin ScheinostDepartment of Biomedical Engineering, Yale School of Engineering and Applied Science, New Haven, CT 06510, USA.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7M
Prospective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
ABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9M
FIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8M
ABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3M
ABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7M
NCATS NIH HHS UL1 TR001863NIDA NIH HHS T32 DA022975NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIGMS NIH HHS T32 GM100884NIMH NIH HHS K00 MH122372NIMH NIH HHS R01 MH121095NIMH NIH HHS RC2 MH089924NIMH NIH HHS RC2 MH089983NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

Neuroimaging-based predictive models continue to improve in performance, yet a widely overlooked aspect of these models is "trustworthiness," or robustness to data manipulations. High trustworthiness is imperative for researchers to have confidence in their findings and interpretations. In this work, we used functional connectomes to explore how minor data manipulations influence machine learning predictions. These manipulations included a method to falsely enhance prediction performance and adversarial noise attacks designed to degrade performance. Although these data manipulations drastically changed model performance, the original and manipulated data were extremely similar (

Indexed as

adversarial attacksconnectomicsfMRIfunctional connectivitymachine learningpredictive modelingtrustworthiness

Identifiers

PMID37521052
PMCPMC10382940
OpenAlexW4376602474

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.