Evidence map›Paper›PMID 37520871›Full record

ArticleCaspian journal of internal medicine2023

Effect of intra-ovarian platelet rich plasma in women with poor ovarian response.

Fatemeh Davari Tanha, Shohreh Salimi Setudeh, Mahbod Ebrahimi, Elham Feizabad, Zahra Khalaj Sereshki, Firoozeh Akbari Asbagh, Hamideh Pakniat, Azadeh Khalili, Zahra Kaveh, Sara Saeedi

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PubMed Full text at PMC Publisher
In one paragraph

Article in Caspian journal of internal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 5 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 5 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Fatemeh Davari TanhaDepartment of Infertility, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Shohreh Salimi SetudehDepartment of Infertility, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Mahbod EbrahimiDepartment of Infertility, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Elham FeizabadDepartment of Infertility, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Zahra Khalaj SereshkiDepartment of Infertility, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Firoozeh Akbari AsbaghDepartment of Infertility, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Hamideh PakniatDepartment of Obstetrics and Gynecology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
Azadeh KhaliliDepartment of Infertility, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Zahra KavehStudent Research Committee, Tehran University of Medical Sciences, Tehran, Iran.
Sara SaeediDepartment of Infertility, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Tehran University of Medical Sciences · IRQazvin University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Poor ovarian responder (POR) women, whose ovarian response to gonadotropin stimulation has decreased, are at higher risk of unsuccessful in-vitro fertilization (IVF). Therefore, this study designed to evaluate the effect of intra-ovarian platelet rich plasma (PRP) on POR women. Methods: This single-arm trial research was done on 20 POR women referred to the IVF Unit, university-based hospital, Tehran, Iran between October 2020 and September 2021. For all participants, autologous PRP was injected into each ovary by transvaginal ultrasound guidance under spinal anesthesia between days 12 and 14 of the menstrual cycle. After 12 weeks of PRP injection, embryo transfers were carried out following our routine IVF department protocol. The study outcomes were the number of mature oocytes, and pregnancy rates. Results: The average age of the participants was 41.80±1.82 yr. The average infertility duration was 9.70±1.89 yrs., with 80% primary infertility type. After PRP injection, follicle-stimulating hormone levels dropped about 1% (P=0.499), anti-Mullerian hormone levels were on average 4.5% higher (P=0.356), and estradiol levels raised by 1.2% (P=0.681). The average number of oocytes and their quality increased after PRP injection, while these changes were not significant (p-value>0.05). Chemical pregnancy was detected in 3 (15%) women and clinical pregnancy was detected only in one person. Conclusion: This study revealed that PRP injection into ovaries of POR women is safe and had a tendency to improve ovarian reserve markers and serum levels of AMH, estradiol, number and quality of oocytes.

Indexed as

Anti-Mullerian hormoneAssisted reproductive techniquesOocyte quality.Ovarian reservePregnancy outcome

Identifiers

PMID37520871
PMCPMC10379785
OpenAlexW4385406983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.