Evidence map›Paper›PMID 37520639›Full record

ArticlePhysics and imaging in radiation oncology2023

Synthetic computed tomography based dose calculation in prostate cancer patients with hip prostheses for magnetic resonance imaging-only radiotherapy.

Lauri Koivula, Tiina Seppälä, Juhani Collan, Harri Visapää, Mikko Tenhunen, Arthur Korhonen

Open access · goldAbstract read
In one paragraph

Article in Physics and imaging in radiation oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lauri KoivulaDepartment of Physics, MATRENA-doctoral programme, University of Helsinki, Gustaf Hällströmin katu 2, 00560 Helsinki, Finland.
Tiina SeppäläComprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4 Building 2, 00290 Helsinki, Finland.
Juhani CollanComprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4 Building 2, 00290 Helsinki, Finland.
Harri VisapääComprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4 Building 2, 00290 Helsinki, Finland.
Mikko TenhunenComprehensive Cancer Center, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4 Building 2, 00290 Helsinki, Finland.
Arthur KorhonenDepartment of Medical Physics, Kymenlaakso Central Hospital, Kymenlaakso Social and Health Services (KymenHVA), Kotkantie 41, 48210 Kotka, Finland.
University of Helsinki · FIKymenlaakson keskussairaala · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Metallic hip prostheses cause substantial artefacts in both computed tomography (CT) and magnetic resonance (MR) images used in radiotherapy treatment planning (RTP) for prostate cancer patients. The aim of this study was to evaluate the dose calculation accuracy of a synthetic CT (sCT) generation workflow and the improvement in implant visibility using metal artefact reduction sequences. Materials and methods: The study included 23 patients with prostate cancer who had hip prostheses, of which 10 patients had bilateral hip implants. An in-house protocol was applied to create sCT images for dose calculation comparison. The study compared prostheses volumes and resulting avoidance sectors against planning target volume (PTV) dose uniformity and organs at risk (OAR) sparing. Results: Median PTV dose difference between sCT and CT-based dose calculation among all patients was 0.1 % (-0.4 to 0.4%) (median(range)). Bladder and rectum differences (V Conclusions: An in-house protocol for generating sCT images for dose calculation provided clinically feasible dose calculation accuracy for prostate cancer patients with hip implants. PTV median dose difference for uni- and bilateral patients with avoidance sectors remained <0.4%. The Outphase images enhanced implant visibility resulting in smaller avoidance sectors, better OAR sparing, and improved PTV uniformity.

Indexed as

ImplantsMRI-onlyProsthesesSynthetic CT images

Identifiers

PMID37520639
PMCPMC10371839
OpenAlexW4383620732

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.