Evidence map›Paper›PMID 37520529›Full record

ReviewFrontiers in immunology2023

Immunomodulatory actions of vitamin D in various immune-related disorders: a comprehensive review.

Amirhossein Ghaseminejad-Raeini, Ali Ghaderi, Amirmohammad Sharafi, Behrad Nematollahi-Sani, Maryam Moossavi, Afshin Derakhshani, Gholamreza Anani Sarab

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
141citing papers in PubMed, 12 pooled it
38.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

141 citing papers in PubMed, 12 syntheses or guidelines pooled it, 150 citations in OpenAlex.

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  13. Effects of vitamin DJournal of the International Society of Sports Nutrition · 2026
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  15. Review
  16. Article
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  18. 25-Hydroxyvitamin D Sufficiency Is Associated With Reduced Atelectasis in Common Variable Immunodeficiency: A Cross-Sectional Study.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Article
  19. Article
  20. Review

81 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Amirhossein Ghaseminejad-RaeiniStudents Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Ali GhaderiStudents Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Amirmohammad SharafiStudents Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Behrad Nematollahi-SaniStudents Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Maryam MoossaviNanobiology and Nanomedicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Afshin DerakhshaniLaboratory of Experimental Pharmacology, IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy.
Gholamreza Anani SarabCellular and Molecular Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Tehran University of Medical Sciences · IRBirjand University of Medical Sciences · IRIstituto Tumori Bari · ITShiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For many years, vitamin D has been acknowledged for its role in maintaining calcium and phosphate balance. However, in recent years, research has assessed its immunomodulatory role and come up with conflicting conclusions. Because the vitamin D receptor is expressed in a variety of immune cell types, study into the precise role of this molecule in diseases, notably autoimmune disorders, has been made possible. The physiologically activated version of vitamin D also promotes a tolerogenic immunological condition in addition to modulating innate and acquired immune cell responses. According to a number of recent studies, this important micronutrient plays a complex role in numerous biochemical pathways in the immune system and disorders that are associated with them. Research in this field is still relatively new, and some studies claim that patients with severe autoimmune illnesses frequently have vitamin D deficiencies or insufficiencies. This review seeks to clarify the most recent research on vitamin D's immune system-related roles, including the pathophysiology of major disorders.

Indexed as

Autoimmune DiseasesVitamin DAdaptive ImmunityHumansImmunity, InnateVitaminsVitamin DVitaminsacquired immunityautoimmune disordersautoimmunityinnate immunityVitamin D

Identifiers

PMID37520529
PMCPMC10379649
OpenAlexW4384406512

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.